Except the blood vessel in-out the cranial cavity and basicranial hole open onto skull, the cranial cavity can be totally regarded as one closed container. Intracranial Pressure (ICP) is fluctuant in brain. The cranial cavity will deform with the changing ICP, which is complex questions and can't be solved the analytical solution. As a very effective numerical method, the finite element is used to analyze the deformation of cranial cavity. Cranial cavity is the hollow sphere formed by the skull and the duramater. There are obvious interfaces among the various parts of outer compact bone, middle cancellous bone, inner compact bone and duramater. In this paper, the matrix of laminated structure and stress-strain relationship of laminated structure have been set up in the cranial cavity, which will be the foundation to analyze the actual deformation of human skull-duramater system with the finite-element software. ? 2011 IEEE.