首页 / 院系成果 / 成果详情页

Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies 期刊论文

编号：

07944c57-8964-41a3-bc0c-a7f09b7502f2
作者：

Teng, Zhaowei#*^[1]Zhu, Yun#^[2]Wu, Feihu^[3];Zhu, Yanhong^[3];Zhang, Xiguang(张锡光)*^[1]Zhang, Chuanlin^[1];Wang, Shuangneng^[1];Zhang, Lei^[4];
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2015 年 10 卷 6 期 ; JUN 1
收录：
摘要：

Objective
To evaluate the association between chronic opioid use for non-cancer pain and fracture risk by conducting a meta-analysis of cohort studies.
Methods
Cohort studies were identified by searching PubMed and EMBASE from their inception to July 2014. A fracture was considered an endpoint. The information was extracted by two authors independently. When the heterogeneity was significant, a random-effects model was used to calculate the overall pooled risk estimates.
Results
Eight cohort studies were included in the final meta-analysis. On the basis of the Newcastle-Ottawa Scale (NOS), six studies were considered to be of high quality. The overall combined relative risk for the use of opioids and fractures was 1.88 (95% confidence interval [CI] 1.51-2.34). A subgroup analysis revealed the sources of heterogeneity. The sensitivity analysis indicated stable results, and no publication bias was observed.
Conclusions
This meta-analysis of cohort studies demonstrates that opioids significantly increase the risk of fractures.
推荐引用方式
GB/T 7714：

Teng Zhaowei,Zhu Yun,Wu Feihu, et al. Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies [J].PLOS ONE,2015,10(6).
APA：

Teng Zhaowei,Zhu Yun,Wu Feihu,Zhu Yanhong,&Zhang Lei.(2015).Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies .PLOS ONE,10(6).
MLA：

Teng Zhaowei, et al. "Opioids Contribute to Fracture Risk: A Meta-Analysis of 8 Cohort Studies" .PLOS ONE 10,6(2015).
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：86  下载次数：0

分享到：

浏览次数：86

下载次数：0

打印次数：0