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Effect of protopine on cytosolic Ca2+ in rabbit platelets 期刊论文

编号：

0a3a51d7-903c-40e8-8be7-6832efbef807
作者：

Shen, ZQ(沈志强)#*; Chen, ZH;Duan, L;
语种：

英文
期刊：

ACTA PHARMACOLOGICA SINICA ISSN：0253-9756 1999 年 20 卷 4 期 (338 - 340) ; APR
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关键词：

protopine adenosine diphosphate arachidonic acids platelet activating factor blood platelets calcium verapamil
摘要：

AIM: To study the influence of protopine (Pro) on the cytoplasmic free Ca2+ concentration ([Ca2+](i)) in rabbit platelets. METHODS: Measurement of [Ca2+](i) of platelets in vitro by Fura 2-AM fluorescence technique. RESULTS: In the presence of CaCl2 1 mmol.L-1, Pro 10, 20, and 40 mu mol.L-1 attenuated the rise in [Ca2+](i) evoked by ADP from (420 +/- 57) to (320 +/- 26), (264 +/- 21), and (180 +/- 14) nmol.L-1, respectively, by arachidonic acid (AA) from (280 +/- 36) to (210 +/- 17), (184 +/- 21), and (143 +/- 16) nmol.L-1, respectively, and by platelet-activating factor (PAF) from (350 +/- 42) to (282 +/- 31), (223 +/- 30), and (165 +/- 15) nmol.L-1, respectively. In the presence of egtazic acid 1 mmol.L-1, Pro 10, 20, and 40 mu mol.L-1 reduced the Ca2+ release induced by ADP, AA, and PAF, respectively. Pro 10, 20; and 40 mu mol.L-1 also decreased ADP-, AA-, and PAF-induced Ca2+ influx. CONCLUSION: Pro inhibited not only Ca2+ release but also the influx of Ca2+.
推荐引用方式
GB/T 7714：

Shen ZQ,Chen ZH,Duan L, et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets [J].ACTA PHARMACOLOGICA SINICA,1999,20(4):338-340.
APA：

Shen ZQ,Chen ZH,Duan L.(1999).Effect of protopine on cytosolic Ca2+ in rabbit platelets .ACTA PHARMACOLOGICA SINICA,20(4):338-340.
MLA：

Shen ZQ, et al. "Effect of protopine on cytosolic Ca2+ in rabbit platelets" .ACTA PHARMACOLOGICA SINICA 20,4(1999):338-340.
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