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Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection 期刊论文

编号：

0dff6e59-afc7-410f-b2c9-9a9943fdfe13
作者：

Udukala, Dinusha N.#^[1]Wang, Hongwang#^[1]Wendel, Sebastian O.#^[1]Malalasekera, Aruni P.#^[1]Samarakoon, Thilani N.^[1];Yapa, Asanka S.^[1];Abayaweera, Gayani^[1];Basel, Matthew T.^[2];Maynez, Pamela^[1];Ortega, Raquel^[1];Toledo, Yubisela^[1];Bossmann, Leonie^[1];Robinson, Colette^[1];Janik, Katharine E.^[1];Koper, Olga B.^[1];Li, Ping^[1];Motamedi, Massoud^[3];Higgins, Daniel A.^[1];Gadbury, Gary^[4];Zhu, Gaohong*^[5]Troyer, Deryl L.*^[2]Bossmann, Stefan H.*^[1]
语种：

英文
期刊：

BEILSTEIN JOURNAL OF NANOTECHNOLOGY ISSN：2190-4286 2016 年 7 卷 (364 - 373) ; MAR 7
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关键词：

biophotonics breast cancer iron/iron oxide nanoparticle liquid biopsy nanodiagnostics detection nanomedicine sub-femtomolar limit of detection
摘要：

Proteases, including matrix metalloproteinases (MMPs), tissue serine proteases, and cathepsins (CTS) exhibit numerous functions in tumor biology. Solid tumors are characterized by changes in protease expression levels by tumor and surrounding tissue. Therefore, monitoring protease levels in tissue samples and liquid biopsies is a vital strategy for early cancer detection. Water-dispersable Fe/Fe3O4-core/shell based nanoplatforms for protease detection are capable of detecting protease activity down to sub-femtomolar limits of detection. They feature one dye (tetrakis(carboxyphenyl) porphyrin (TCPP)) that is tethered to the central nanoparticle by means of a protease-cleavable consensus sequence and a second dye (Cy 5.5) that is directly linked. Based on the protease activities of urokinase plasminogen activator (uPA), MMPs 1, 2, 3, 7, 9, and 13, as well as CTS B and L, human breast cancer can be detected at stage I by means of a simple serum test. By monitoring CTS B and L stage 0 detection may be achieved. This initial study, comprised of 46 breast cancer patients and 20 apparently healthy human subjects, demonstrates the feasibility of protease-activity-based liquid biopsies for early cancer diagnosis.
推荐引用方式
GB/T 7714：

Udukala Dinusha N.,Wang Hongwang,Wendel Sebastian O., et al. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection [J].BEILSTEIN JOURNAL OF NANOTECHNOLOGY,2016,7:364-373.
APA：

Udukala Dinusha N.,Wang Hongwang,Wendel Sebastian O.,Malalasekera Aruni P.,&Bossmann Stefan H..(2016).Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection .BEILSTEIN JOURNAL OF NANOTECHNOLOGY,7:364-373.
MLA：

Udukala Dinusha N., et al. "Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection" .BEILSTEIN JOURNAL OF NANOTECHNOLOGY 7(2016):364-373.
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