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A new insulin-enhancing agent: [N,N '-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity 期刊论文

编号：

0f862a58-27a1-4350-bd23-6947ffe65064
作者：

Xie, Mingjin#*^[1]Li, Ling(李玲)^[2]Yang, XiaoDa^[3];Liu, Weiping^[4];Yan, Shiping^[5];Niu, Yanfen(牛艳芬)^[2]Meng, Zhaohui(孟照辉)^[6]
语种：

英文
期刊：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ISSN：0223-5234 2010 年 45 卷 6 期 (2327 - 2335) ; JUN
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关键词：

Insulin-enhancing Salen-type ligands Caco-2 cells
摘要：

A new insulin-enhancing agent: [N,N'-bis(4-hydroxysalicylidene)-o-phenylene-diamine] oxovanadium (IV) (BPOV) was synthesized and characterized by X-ray crystallography. BPOV was administered intragastrically to STZ-diabetic rats for 4 weeks. The results showed that BPOV could significantly decrease the blood glucose level and ameliorated impaired glucose tolerance in STZ-diabetic rats. BPOV has been further tested on insulin, glycogen and serum lipid studies. The results suggested BPOV has glucose-lowering activity in diabetic rats, as well as improved the disorder of lipid metabolism in diabetes. BPOV had permeability above 10(-5) cm s(-1). It was suggested good lipophilic properties. The cytotoxicity of BPOV on Caco-2 cells was measured by MTT assay which suggested BPOV have higher effect on impairment of cellular associated with lower level capacity of cellular accumulation.
推荐引用方式
GB/T 7714：

Xie Ming-jin,Li Ling,Yang Xiao-Da, et al. A new insulin-enhancing agent: [N,N '-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity [J].EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2010,45(6):2327-2335.
APA：

Xie Ming-jin,Li Ling,Yang Xiao-Da,Liu Wei-ping,&Meng Zhao-hui.(2010).A new insulin-enhancing agent: [N,N '-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,45(6):2327-2335.
MLA：

Xie Ming-jin, et al. "A new insulin-enhancing agent: [N,N '-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity" .EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 45,6(2010):2327-2335.
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