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Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program 期刊论文

编号：

142840c5-017d-48e8-bf4f-7835a2e91a61
作者：

Zhang, Yawei#^[1]Zhang, Feifei^[1];Wang, Hui*^[1]Zhao, Chunjiang^[1];Wang, Zhanwei^[1];Cao, Bin^[2];Du, Yan(杜艳)^[3]Feng, Xianju^[4];Hu, Yunjian^[5];Hu, Bijie^[6];Ji, Ping^[7];Liu, Zhiyong^[8];Liu, Yong^[9];Liao, Wanzhen^[10];Lu, Juan^[11];Sun, Hongli^[12];Wang, Zhongxin^[13];Xu, Xiuli^[14];Xu, Xuesong^[15];Yang, Qing^[16];Yu, Yunsong^[17];Zhang, Rong^[18];Zhuo, Chao^[19];
语种：

英文
期刊：

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE ISSN：2213-7165 2016 年 5 卷 (36 - 41) ; JUN
收录：
关键词：

Antimicrobial resistance Surveillance Community-acquired respiratory tract infection
摘要：

This study investigated the antimicrobial susceptibilities of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolates causing adult community-acquired respiratory tract infections (CARTIs) in China. A multicentre resistance surveillance study (CARTIPS) investigating 1046 clinical isolates from 19 hospitals in China was conducted from 2013 to 2014. Based on the minimum inhibitory concentration (MIC) breakpoints of oral penicillin, the percentages of penicillin-resistant, penicillin-intermediate and penicillin-susceptible S. pneumoniae were 44.1%, 13.7%, and 42.2%, respectively. The rates of penicillin-non-susceptible S. pneumoniae ranged from 27.9% to 72.2% in different cities, with the highest rate in Nanchang. Macrolides, including azithromycin, clarithromycin and erythromycin, showed the lowest activities against S. pneumoniae isolates, with resistance rates of 90.5%, 92.2% and 93.0%, respectively. However, 98% of these strains were susceptible to levofloxacin and moxifloxacin. For H. influenzae isolates, most of the antimicrobials agents exhibited good activities. However, ampicillin and trimethoprim/sulfamethoxazole showed relatively lower activity against H. influenzae, with resistance rates of 35.0% and 54.4%, respectively. beta-lactamase production rates amongst H. influenzae and M. catarrhalis were 31.0% and 87.1%, respectively. In addition, a total of 15 beta-lactamase-negative ampicillin-resistant (BLNAR) strains identified in this study were resistant to ampicillin, amoxicillin/clavulanic acid, cefaclor and cefuroxime. Most of the antimicrobial agents showed excellent activity against M. catarrhalis, with susceptibility rates of > 90%. The results from the current study confirmed the regional variations in antimicrobial susceptibility of major CARTI pathogens and provided some choices for the treatment of these organisms. Continuous national surveillance of the epidemiology of CARTIs is strongly warranted in China. (C) 2016 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Zhang Yawei,Zhang Feifei,Wang Hui, et al. Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program [J].JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,2016,5:36-41.
APA：

Zhang Yawei,Zhang Feifei,Wang Hui,Zhao Chunjiang,&Zhuo Chao.(2016).Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program .JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE,5:36-41.
MLA：

Zhang Yawei, et al. "Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis isolated from community-acquired respiratory tract infections in China: Results from the CARTIPS Antimicrobial Surveillance Program" .JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE 5(2016):36-41.
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