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Increased levels of plasma alpha 2-Heremans-Schmid glycoprotein in Yi Chinese patients with lower extremity atherosclerosis diseases due to type 2 diabetes mellitus 期刊论文

编号：

38013205-81f7-4e36-a649-72c4b699731b
作者：

Lan, Danfeng#^[1]Zhao, Yan#^[1]Wang, Ling^[2];Wang, Yan^[1];Tan, Hong^[1];Cao, Yu^[3];Yang, Qiuping(杨秋萍)*^[1]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE ISSN：1940-5901 2016 年 9 卷 6 期 (11467 - 11475)
收录：
关键词：

Alpha 2-Heremans Schmid glycoprotein lower extremity atherosclerosis disease type 2 diabetes predictor Yi Chinese people
摘要：

The study aimed to investigate the value of plasma alpha 2-Heremans-Schmid glycoprotein (AHSG) levels for predicting the presence and severity of lower extremity atherosclerosis disease (LEASD) in Yi Chinese patients with type 2 diabetes mellitus (T2DM). A total of 128 consecutive patients with T2DM and 120 normal controls were recruited. Plasma AHSG levels were analyzed by enzyme-linked immunosorbent assay (ELISA). LEASD was diagnosed by color Doppler ultrasound examination, and its severity was assessed by the sum of each atherosclerosis (AS) score, including intima-media thickness (IMT), degree of sclerosis, plaques, and luminal stenosis. T2DM subjects had significantly higher AHSG levels than normal controls (348.88 +/- 48.18 mu g/ml vs. 283.09 +/- 40.72 mu g/ml, P < 0.01). T2DM patients with LEASD showed significantly higher AHSG levels than T2DM patients without LEASD (363.80 +/- 48.35 mu g/ml vs. 332.48 +/- 42.66 mu g/ml, P < 0.01). The difference remained statistically significant after adjusting for all other potential confounders between groups using covariance analysis. AHSG was positively correlated with homeostasis model assessment-insulin resistance (HOMA-IR) and AS scores by Pearson's correlation analysis (r = 0.175, P < 0.05; r = 0.407, P < 0.01, respectively). HOMA-IR was independently associated with AHSG in a multivariate linear regression analysis (t = 2.150, P < 0.05). Logistic regression analysis revealed that AHSG was an independent risk factor for T2DM and for T2DM complicated by LEASD (OR = 1.070, 95% CI: 1.027-1.116, P < 0.01; OR = 1.024, 95% CI: 1.011-1.037, P < 0.01, respectively). An increased level of plasma AHSG might serve as a potential predictor of the presence and development of T2DM and LEASD caused by T2DM in Yi Chinese patients.
推荐引用方式
GB/T 7714：

Lan Danfeng,Zhao Yan,Wang Ling, et al. Increased levels of plasma alpha 2-Heremans-Schmid glycoprotein in Yi Chinese patients with lower extremity atherosclerosis diseases due to type 2 diabetes mellitus [J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,2016,9(6):11467-11475.
APA：

Lan Danfeng,Zhao Yan,Wang Ling,Wang Yan,&Yang Qiuping.(2016).Increased levels of plasma alpha 2-Heremans-Schmid glycoprotein in Yi Chinese patients with lower extremity atherosclerosis diseases due to type 2 diabetes mellitus .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9(6):11467-11475.
MLA：

Lan Danfeng, et al. "Increased levels of plasma alpha 2-Heremans-Schmid glycoprotein in Yi Chinese patients with lower extremity atherosclerosis diseases due to type 2 diabetes mellitus" .INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9,6(2016):11467-11475.
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