Background: The -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulgaris risk.
Methods: We searched in Pubmed, Embase, Web of Science and CNKI for studies evaluating the association between the 308 G/A gene polymorphism and acne vulgaris risk. Data were extracted and statistical analysis was performed using STATA 12.0 software.
Results: A total of five publications involving 1553 subjects (728 acne vulgaris cases and 825 controls) were included in this meta-analysis. Combined analysis revealed a significant association between this polymorphism and acne vulgaris risk under recessive model (OR = 2.73, 95% CI: 1.37-5.44, p = 0.004 for AA vs. AG + GG). Subgroup analysis by ethnicity showed that the acne vulgaris risk associated with the -308 G/A gene polymorphism was significantly elevated among Caucasians under recessive model (OR = 2.34, 95% CI: 1.13-4.86, p = 0.023).
Conclusion: This meta-analysis suggests that the -308 G/A polymorphism in the TNF gene contributes to acne vulgaris risk, especially in Caucasian populations. Further studies among different ethnicity populations are needed to validate these findings.
[1]Yunnan Univ, Lab Conservat & Utilizat Bioresources, Kunming, Yunnan, Peoples R China.
[2]Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming, Yunnan, Peoples R China.
[3]Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming, Yunnan, Peoples R China.
[4]Inst Dermatol & Venereol Yunnan Prov, Kunming, Yunnan, Peoples R China.
[5]Chinese Acad Sci, State Key Lab Genet Resources & Evolut, Kunming, Yunnan, Peoples R China.
[6]Chinese Acad Sci, Yunnan Lab Mol Biol Domest Anim, Kunming Inst Zool, Kunming, Yunnan, Peoples R China.
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