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Identification of Environmental Factors Associated with Inflammatory Bowel Disease in a Southwestern Highland Region of China: A Nested Case-Control Study 期刊论文

编号：

4a354a63-3957-4595-aead-3ee27bd1a986
作者：

Niu, Junkun(牛俊坤)#^[1]Miao, Jiarong(缪佳蓉)#^[1]Tang, Yuan^[2];Nan, Qiong(南琼)^[1]Liu, Yan^[1];Yang, Gang(杨刚)^[1]Dong, Xiangqian(董向前)^[1]Huang, Qi^[1];Xia, Shuxian^[1];Wang, Kunhua*^[3]Miao, Yinglei(缪应雷)*^[1]
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2016 年 11 卷 4 期 ; APR 12
收录：
摘要：

Background
The aim of this study was to examine environmental factors associated with inflammatory bowel disease (IBD) in Yunnan Province, a southwestern highland region of China.
Methods
In this nested case-control study, newly diagnosed ulcerative colitis (UC) cases in 2 cities in Yunnan Province and Crohn's disease (CD) cases in 16 cities in Yunnan Province were recruited between 2008 and 2013. Controls were matched by geography, sex and age at a ratio of 1:4. Data were collected using the designed questionnaire. Conditional logistic regression models were used to estimate adjusted odds ratios (ORs).
Results
A total of 678 UC and 102 CD cases were recruited. For UC, various factors were associated with an increased risk of developing UC: dietary habits, including frequent irregular meal times; consumption of fried foods, salty foods and frozen dinners; childhood factors, including intestinal infectious diseases and frequent use of antibiotics; and other factors, such as mental labor, high work stress, use of non-aspirin non-steroidal anti-inflammatory drugs and allergies (OR > 1, p < 0.05). Other factors showed a protective effect: such as consumption of fruits, current smoking, physical activity, and drinking tea (OR < 1, p < 0.05). For CD, appendectomy and irregular meal times increased the disease risk (OR > 1, p < 0.05), whereas physical activity may have reduced this risk (OR < 1, p < 0.05).
Conclusions
This study is the first nested case-control study to analyze the association between environmental factors and IBD onset in a southwestern highland region of China. Certain dietary habits, lifestyles, allergies and childhood factors may play important roles in IBD, particularly UC.
推荐引用方式
GB/T 7714：

Niu Junkun,Miao Jiarong,Tang Yuan, et al. Identification of Environmental Factors Associated with Inflammatory Bowel Disease in a Southwestern Highland Region of China: A Nested Case-Control Study [J].PLOS ONE,2016,11(4).
APA：

Niu Junkun,Miao Jiarong,Tang Yuan,Nan Qiong,&Miao Yinglei.(2016).Identification of Environmental Factors Associated with Inflammatory Bowel Disease in a Southwestern Highland Region of China: A Nested Case-Control Study .PLOS ONE,11(4).
MLA：

Niu Junkun, et al. "Identification of Environmental Factors Associated with Inflammatory Bowel Disease in a Southwestern Highland Region of China: A Nested Case-Control Study" .PLOS ONE 11,4(2016).
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