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A Novel Bioactive Peptide with Myotropic Activity from Wasp Venoms 期刊论文

编号：

62571de7-5ccd-439a-b291-3db694a39bf3
作者：

Yan, Hongli[0];Chen, Wenlin[1](陈文林); Chen, Lingling[2];Lai, Ren[3];Liu, Jingze[4];
地址：

Nanjing Agricultural University, Life Sciences College,Nanjing,China[0];Kunming Medical College, Yunnan Clinical Research Center of Breast Cancer,Kunming,China[1];Kunming Medical College, Clinical Laboratory,Kunming,China[2];Chinese Academy of Sciences, Sino-African Joint Research Center,Beijing,China[3];Hebei Normal University, College of Life Sciences,Shijiazhuang,China[4];
语种：

英文
期刊：

Chinese Journal of Natural Medicines ISSN：1875-5364 2011 年 9 卷 4 期 (317 - 320)
收录：
关键词：

Contraction Smooth muscle Vespa bicolor Wasp venoms
摘要：

Aim: To study the chemical constituents of the venom of Vespa bicolor Fabricius collected from Shanxi Province, China. Methods: Gel chromatography and HPLC were applied to isolate a peptide from the venom. Mass spectrometry and Edman degradation were used for its structural characterization. The cDNA encoding vespin-BF precursor was cloned from the cDNA library of the venomous glands. The synthetic peptide was used for its bioassay. Results: A novel bioactive peptide (vespin-BF) with unique primary structure was purified and characterized. Its amino acid sequence was determined as TYQRKMAITAGAVKHRLMSTTIIIILVRIE YLRDNMVISLESSF. Vespin-BF induced contraction of isolated ileum smooth muscle. The precursor is composed of 67 amino acid residues including the predicted signal peptide and mature vespin-BF. A di-basic enzymatic processing site (-KR-) was located between the signal and the mature peptide. BLAST search indicated that vespin-BF shows obvious similarity to vespin identified from the venoms of Vespa magnifica. Conclusion: A novel bioactive peptide from the wasp venoms was characterized. ? 2011 China Pharmaceutical University.
推荐引用方式
GB/T 7714：

Yan Hongli[0],Chen Wenlin[1],Chen Lingling[2], et al. A Novel Bioactive Peptide with Myotropic Activity from Wasp Venoms [J].Chinese Journal of Natural Medicines,2011,9(4):317-320.
APA：

Yan Hongli[0],Chen Wenlin[1],Chen Lingling[2],Lai Ren[3],&Liu Jingze[4].(2011).A Novel Bioactive Peptide with Myotropic Activity from Wasp Venoms .Chinese Journal of Natural Medicines,9(4):317-320.
MLA：

Yan Hongli[0], et al. "A Novel Bioactive Peptide with Myotropic Activity from Wasp Venoms" .Chinese Journal of Natural Medicines 9,4(2011):317-320.

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