[1]Thoracic Surgery, Third Affiliated Hospital, Kunming Medical University, Kunming, China.
Background: To explore the expression of Notch1 and Notch2 in Xuanwei female patients with lung cancer and its clinical significance. Methods: The expression of Notch1 and Notch2 in the cancer tissue and distant normal tissue from 54 Xuanwei female patients with lung cancer was detected using immunohistochemical SP method. By combining with the clinicopathological characteristics and follow-up files, the functions of Notch1 and Notch2 in Xuanwei female patients with lung cancer for pathological and prognostic assessment were investigated. Results: Both Notch-1 and Notch-2 proteins were mainly expressed in cytoplasm. The positive rates of Notch-1 and Notch-2 expression in the lung cancer tissue of Xuanwei females were dramatically higher than in distant normal tissue (P<0.05). There was statistical significance by comparison to the expression of Notch-1 and Notch-2 in patients with different clinical stagings, differentiated degrees and presence or absence of lymph node metastasis (P<0.05). The expression of Notch-1 and Notch-2 proteins was positively correlated in Xuanwei female patients with lung cancer. Conclusion: The expression of Notch-1 and Notch-2 proteins goes up abnormally in the lung cancer tissue of Xuanwei females, and their expression levels combined with clinical staging has a certain clinical significance for prognostic assessment in Xuanwei female patients with lung cancer.
(8.0+极速模式)