首页 / 院系成果 / 成果详情页

CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling 期刊论文

编号：

705db8a6-9395-4e37-89ce-b3040cafa337
作者：

Zhang, Jiaping#^[1,2]Dong, Jianda^[2,3,4];Gu, Hua(顾华)^[5,6]Yu, Sidney^[2];Zhang, Xiaohu^[2];Gou, Yulin^[2];Xu, Wenming^[2];Burd, Andrew^[5];Huang, Lin^[5];Miyado, Kenji^[7];Huang, Yuesheng*^[1]Chan, Hsiao Chang*^[2]
语种：

英文
期刊：

JOURNAL OF INVESTIGATIVE DERMATOLOGY ISSN：0022-202X 2012 年 132 卷 1 期 (226 - 236) ; JAN
收录：
摘要：

Cutaneous injury triggers a cascade of signaling events essential for wound re-epithelialization. CD9, a cell-surface protein, has been implicated in a number of cellular processes by coupling to intracellular signaling; however, its exact role in wound healing remains unidentified. We reported that CD9 was downregulated in migrating epidermis, and reelevated to basal level when re-epithelialization was completed. Although low level of CD9 appears to be required for normal wound healing, a significant healing delay was found in CD9-null mice, with wounds gaping wider on day 5 and day 7 post wounding. Further analysis showed that re-epithelialization was adversely affected in CD9-null mice, due to impaired migration of epidermis. Notably, CD9 deficiency caused a persistent enhancement of C-JUN NH2 terminal kinase (JNK) signaling primarily in migrating epidermis with abnormal elevation of matrix metalloproteinase (MMP)-9 detected in CD9-null wounds, leading to excessive degradation of type IV collagen, and thus a defective basement membrane at the wound site. JNK suppression reduced MMP-9 production and therefore ameliorated the healing delay with the appearance of significantly elongated migrating epidermis in CD9-null mice. Our study demonstrated the importance of CD9 in wound re-epithelialization, linking this molecule directly to basement membrane formation and epidermal migration through participating in the regulation of the JNK/MMP-9 pathway.
推荐引用方式
GB/T 7714：

Zhang Jiaping,Dong Jianda,Gu Hua, et al. CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling [J].JOURNAL OF INVESTIGATIVE DERMATOLOGY,2012,132(1):226-236.
APA：

Zhang Jiaping,Dong Jianda,Gu Hua,Yu Sidney,&Chan Hsiao Chang.(2012).CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling .JOURNAL OF INVESTIGATIVE DERMATOLOGY,132(1):226-236.
MLA：

Zhang Jiaping, et al. "CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling" .JOURNAL OF INVESTIGATIVE DERMATOLOGY 132,1(2012):226-236.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：58  下载次数：0

分享到：

浏览次数：58

下载次数：0

打印次数：0