首页 / 院系成果 / 成果详情页

MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1 期刊论文

编号：

7b8d9bd3-845f-4724-9cfa-fe8229cbeb81
作者：

Zhang, Ming(张明)#^[1]Gao, Chang'e(高嫦娥)#^[2]Yang, Yi^[1];Li, Gaofeng(李高峰)^[3]Dong, Jian^[4];Ai, Yiqin^[1];Ma, Qianli^[3];Li, Wenhui(李文辉)*^[1]
语种：

英文
期刊：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ISSN：1015-8987 2017 年 42 卷 1 期 (211 - 221)
收录：
关键词：

Non-small cell lung cancer (NSCLC) miR-424 TNFAIP1 Cell migration and invasion
摘要：

Background/Aims: This study aimed to investigate the potential roles of miR-424 expression in non-small cell lung cancer (NSCLC) metastasis and growth and its underlying mechanism. Methods: The expression of miR-424 in two NSCLC cell lines (A549 and H1975) was altered by transfection with miR-424 mimic and inhibitor. Effects of miR-424 overexpression and suppression on cells migration, invasion and colony formation were analyzed. Target genes for miR-424 were predicted using bioinformatics method and then verified using luciferase assay. Effects of miR-424 expression on cell migration, invasion and proliferation were reanalyzed on the condition of TNFAIP1 was silenced. Moreover, TNFAIP1 silencing and miR-424 modified A549 cells were subcutaneous injected into node BALB/c mice to confirm the regulation of miR-424 on TNFAIP1 in regulating tumor growth. Results: Compared with the control, miR-424 overexpression significantly increased the migrated and invaded cells, as well as the proliferated colonies. TNFAIP1 was a predicted target gene for miR-424, and was negatively regulated by miR-424. TNFAIP1 silence significantly increased the migrated and invaded cells compared to that in control, while these increases were abolished by miR-424 suppression. Animal experiment further evidenced miR-424 affected tumor growth by regulating TNFAIP1. Conclusions: These data demonstrate that miR-424 may be a contributor for NSCLC progression and metastasis through involving in cell migration, invasion and proliferation via inhibiting TNFAIP1. This study may provide theoretical basis for miR-424 in NSCLC target therapeutic treatment. (C) 2017 The Author(s) Published by S. Karger AG, Basel
推荐引用方式
GB/T 7714：

Zhang Ming,Gao Chang'e,Yang Yi, et al. MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1 [J].CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2017,42(1):211-221.
APA：

Zhang Ming,Gao Chang'e,Yang Yi,Li Gaofeng,&Li Wenhui.(2017).MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1 .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,42(1):211-221.
MLA：

Zhang Ming, et al. "MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1" .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 42,1(2017):211-221.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：95  下载次数：0

分享到：

浏览次数：95

下载次数：0

打印次数：0