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CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease 期刊论文

编号：

7b9a8cdd-30b6-42ea-9dcf-1cb572b592d0
作者：

Zhang, XiaoFang#^[1]Zhao, YanFeng^[2];Zhu, ShunWei^[3];Huang, WeiJie^[3];Luo, Yan^[3];Chen, QingYing^[3];Ge, LiJun^[4];Li, RunSheng^[2];Wang, JianFei^[4];Sun, Mu^[3];Xiao, ZhiCheng(肖志成)*^[1,5]Fan, GuoHuang*^[2,6,7,8,9]
语种：

英文
期刊：

JOURNAL OF ALZHEIMERS DISEASE ISSN：1387-2877 2015 年 48 卷 1 期 (89 - 104)
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关键词：

Caspase-3 CXCL1 CXCR2 hippocampal neurons tau cleavage
摘要：

Truncation of tau protein is considered an early event in Alzheimer's disease (AD) and is believed to play a major pathogenic role in sporadic AD. However, causative factors that trigger tau truncation in AD remain poorly understood. In the present study, we demonstrate that CXCL1 (C-X-C motif ligand 1), a specific ligand for the chemokine receptor CXCR2, induced cleavage of tau at ASP(421) in a caspase-3-dependent manner in long-term but not short-term cultured neurons. The cleaved tau formed varicosities or bead-like structures along the neurites, an abnormal distribution of tau induced by CXCL1 that has not been observed previously. CXCL1-induced activation of GSK3 beta and the subsequent phosphorylation of tau preceded and were required for caspase-3 activation and tau cleavage. Moreover, intrahippocampal microinjection of lentiviral CXCL1 induced tau cleavage in hippocampal neurons in aged (15-18 months of age) but not adult mice (5-10 months of age). Our data highlight a new role of CXCR2 in tau cleavage and suggest that targeting CXCR2 may offer therapeutic benefits to patients with AD and potentially other tauopathies.
推荐引用方式
GB/T 7714：

Zhang Xiao-Fang,Zhao Yan-Feng,Zhu Shun-Wei, et al. CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease [J].JOURNAL OF ALZHEIMERS DISEASE,2015,48(1):89-104.
APA：

Zhang Xiao-Fang,Zhao Yan-Feng,Zhu Shun-Wei,Huang Wei-Jie,&Fan Guo-Huang.(2015).CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease .JOURNAL OF ALZHEIMERS DISEASE,48(1):89-104.
MLA：

Zhang Xiao-Fang, et al. "CXCL1 Triggers Caspase-3 Dependent Tau Cleavage in Long-Term Neuronal Cultures and in the Hippocampus of Aged Mice: Implications in Alzheimer's Disease" .JOURNAL OF ALZHEIMERS DISEASE 48,1(2015):89-104.
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