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Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells 期刊论文

编号：

80a79176-7472-4c18-9996-cdad23a53895
作者：

Yang, Delin(杨德林)#^[1]Wang, Jiansong(王剑松)*^[1]Li, Jun^[2];Wang, Haifeng(王海峰)*^[1]He, Huihai^[1];Zhang, Chao^[1];Wang, Kai^[1];Xu, Hongyi^[1];
语种：

英文
期刊：

MOLECULAR MEDICINE REPORTS ISSN：1791-2997 2012 年 5 卷 1 期 (266 - 269) ; JAN
收录：
关键词：

bladder carcinoma membrane toxin 12 CXCR4 proliferation invasiveness
摘要：

We investigated the effect of membrane toxin 12 (MT-12), isolated from Naja naja atra, a species of Chinese Cobra, on the proliferation and invasion of human bladder cancer EJ cells and studied its mechanisms using MTT assay, Transwell chamber invasion assay, scanning electron microscopy and flow cytometry. The results indicated that MT-12 inhibited the proliferation of bladder cancer cells in a dose-dependent manner. The half maximal inhibitory concentration (IC50) after 72 h was 0.66 mu g/ml. The invasion of cells decreased with increasing doses of MT-12 (0.125-0.5 mu g/ml, P<0.001). Expression of CXCR4 decreased with the effect of MT-12 for a particular concentration range (0.125-0.5 mu g/ml). To conclude, MT-12 is capable of inhibiting the proliferation and invasion of bladder cancer EJ cells. This mechanism may be associated with reduced expression of CXCR4 protein.
推荐引用方式
GB/T 7714：

Yang Delin,Wang Jiansong,Li Jun, et al. Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells [J].MOLECULAR MEDICINE REPORTS,2012,5(1):266-269.
APA：

Yang Delin,Wang Jiansong,Li Jun,Wang Haifeng,&Xu Hongyi.(2012).Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells .MOLECULAR MEDICINE REPORTS,5(1):266-269.
MLA：

Yang Delin, et al. "Effect of membrane toxin 12 isolated from Naja naja atra on proliferation and invasion of human bladder cancer EJ cells" .MOLECULAR MEDICINE REPORTS 5,1(2012):266-269.
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