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Synthesis of 4-(5-Benzyl-2-phenylpyrimidin-4-yl)morpholines as Novel PI3K Inhibitors Via Acetates of Baylis-Hillman Adducts and Benzamidines 期刊论文

编号：

838c8a21-4b7d-4ad4-9648-d1fef778894d
作者：

Yang, Chunhao#*; Yu, Haofei(于浩飞); Yang, Na;Meng, Linghua;Xu, Jing;Zhang, Rongping(张荣平); Xie, Yuyuan;Ding, Jian;
语种：

英文
期刊：

LETTERS IN ORGANIC CHEMISTRY ISSN：1570-1786 2009 年 6 卷 2 期 (134 - 140) ; MAR
收录：
关键词：

Baylis-Hillman adducts PI3K inhibitors pyrimidin-4(3H)-one dihydropyrimidin-4(3H)-one
摘要：

The key intermediates 5-benzyl-2-phenylpyrimidin-4(3H)-ones or ( E)-5-benzylidene-2-phenyl-5,6-dihydropyrimidin-4( 3H)-ones were obtained conveniently by cyclization of the acetates of Baylis-Hillman adducts and benzamidine hydrochloride in the presence of sodium ethoxide at room temperature. Chlorination of pyrimidinones with phosphorus oxychloride and subsequent treatment with morpholine and demethylation yielded PI3K inhibitors.
推荐引用方式
GB/T 7714：

Yang Chunhao,Yu Haofei,Yang Na, et al. Synthesis of 4-(5-Benzyl-2-phenylpyrimidin-4-yl)morpholines as Novel PI3K Inhibitors Via Acetates of Baylis-Hillman Adducts and Benzamidines [J].LETTERS IN ORGANIC CHEMISTRY,2009,6(2):134-140.
APA：

Yang Chunhao,Yu Haofei,Yang Na,Meng Linghua,&Ding Jian.(2009).Synthesis of 4-(5-Benzyl-2-phenylpyrimidin-4-yl)morpholines as Novel PI3K Inhibitors Via Acetates of Baylis-Hillman Adducts and Benzamidines .LETTERS IN ORGANIC CHEMISTRY,6(2):134-140.
MLA：

Yang Chunhao, et al. "Synthesis of 4-(5-Benzyl-2-phenylpyrimidin-4-yl)morpholines as Novel PI3K Inhibitors Via Acetates of Baylis-Hillman Adducts and Benzamidines" .LETTERS IN ORGANIC CHEMISTRY 6,2(2009):134-140.
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