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Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway 期刊论文

编号：

8c77f6fa-478c-4219-a7c3-94298f29ac8b
作者：

Luo, Zhiling(骆志玲)#^[1]Shen, Yan(沈艳)^[1]Chen, Wei^[2];Ma, Xuejuan^[1];Liu, Liping^[1];Huang, Xiaoqin^[3,4];Yang, Zhaoqing(杨照青)^[3,4]Sun, Hao*^[3,4]
语种：

英文
期刊：

GENETIC TESTING AND MOLECULAR BIOMARKERS ISSN：1945-0265 2017 年 21 卷 7 期 (440 - 444) ; JUL
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关键词：

congenital heart disease Ras-MAPK pathway tag SNP TBX20 association analysis
摘要：

Aims: The present study was performed to determine whether there are variants in TBX20 and genes of the Ras-MAPK pathway associated with nonsyndromic congenital heart disease (ns-CHD).
Materials and Methods: A total of 223 ns-CHD patients and 273 healthy controls from China were selected as study subjects to perform an association analysis using 22 tag single-nucleotide polymorphisms (tag SNPs) located either in one of three genes in the Ras-MAPK pathway (MAP2K2, BRAF, and RAF1) or the TBX20 gene that have previously been associated with syndromic congenital heart disease.
Results: The results showed that none of these tag SNPs are associated with ns-CHD.
Conclusions: The results suggested that these disease-causing genes, which were previously discovered in familial cases, might not be the major genetic factors causing the development of ns-CHD in Chinese.
推荐引用方式
GB/T 7714：

Luo Zhiling,Shen Yan,Chen Wei, et al. Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway [J].GENETIC TESTING AND MOLECULAR BIOMARKERS,2017,21(7):440-444.
APA：

Luo Zhiling,Shen Yan,Chen Wei,Ma Xuejuan,&Sun Hao.(2017).Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway .GENETIC TESTING AND MOLECULAR BIOMARKERS,21(7):440-444.
MLA：

Luo Zhiling, et al. "Association Analysis of Nonsyndromic Congenital Heart Disease and Tag Single Nucleotide Polymorphisms of TBX20 and Genes in the Ras-MAPK Pathway" .GENETIC TESTING AND MOLECULAR BIOMARKERS 21,7(2017):440-444.
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