首页 / 院系成果 / 成果详情页

L-type Ca2+ channel blocker attenuates impairment induced by acidosis in hippocampal neurons 期刊论文

编号：

8cd44e64-0ea2-4488-95e0-19ce84fa82da
作者：

Zeng, Xianghui#*^[1]Zhang, Yanli(张雁丽)^[2]Qing, Chen(卿晨)^[2]Zhang, Hongbin^[1];
语种：

英文
期刊：

PHARMAZIE ISSN：0031-7144 2013 年 68 卷 11 期 (889 - 892) ; NOV
收录：
摘要：

Accumulation of acid in the brain during ischemia may contribute to the activation of voltage-gated Ca2+ channels and subsequent neuronal injury. However, information regarding the role of L-type Ca2+ channel under acidosis remains unclear. In the present study, we examined the role of L-type Ca2+ channel in acidosis induced neuronal death and subsequent pathogenesis events responsible for neuron degeneration. Here we report that preincubation of cells with nifedipine (5 mu M, 10 mu M), an inhibitor of L-type Ca2+ channel markedly reduced neuronal death induced by moderate extracellular acidosis (pH 6.5) on cultured hippocampus neurons. Furthermore, nifedipine decreased the hippocampus neuronal swelling, as well as the accumulation of Ca2+ and collapse of mitochondrial membrane potential induced by acidosis. These findings demonstrate that pharmacological inhibition of L-type Ca2+ channel would attenuate neuronal degeneration caused by toxic low pH exposure in rat hippocampus neuron.
推荐引用方式
GB/T 7714：

Zeng Xianghui,Zhang Yanli,Qing Chen, et al. L-type Ca2+ channel blocker attenuates impairment induced by acidosis in hippocampal neurons [J].PHARMAZIE,2013,68(11):889-892.
APA：

Zeng Xianghui,Zhang Yanli,Qing Chen,Zhang Hongbin.(2013).L-type Ca2+ channel blocker attenuates impairment induced by acidosis in hippocampal neurons .PHARMAZIE,68(11):889-892.
MLA：

Zeng Xianghui, et al. "L-type Ca2+ channel blocker attenuates impairment induced by acidosis in hippocampal neurons" .PHARMAZIE 68,11(2013):889-892.
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：85  下载次数：0

分享到：

浏览次数：85

下载次数：0

打印次数：0