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MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma 期刊论文

编号：

9b4d3ba5-3ded-4877-864d-790ac138be3c
作者：

Zhuang, Li(庄莉)#*^[1]Shou, Tao^[2];Li, Ke(李科)^[3]Gao, ChunLin^[3];Duan, LinCan(段林灿)^[4]Fang, LiZhou^[5];Zhang, QinYong^[6];Chen, ZongNing^[7];Zhang, Chao^[8];Yang, ShouTao^[9];Li, GaoFeng(李高峰)*^[4]
语种：

英文
期刊：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE ISSN：1582-1838 2017 年 21 卷 11 期 (2852 - 2862) ; NOV
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关键词：

microRNA-30e-5p lung adenocarcinoma growth PTPN13
摘要：

Aberrant microRNA expression is involved in the regulation of various cellular processes, such as proliferation and metastasis in multiple diseases including cancers. MicroRNA-30e-5p (miR-30e) was previously reported as an oncogenic or tumour suppressing miRNA in some malignancies, but its function in lung adenocarcinoma (LAC) remains largely undefined. In this study, we found that the expression of miR-30e was increased in LAC tissues and cell lines, associated with tumour size and represented an independent prognostic factor for overall survival and recurrence of LAC patients. Further functional experiments showed that knockdown of miR-30e suppressed cell growth while its overexpression promoted growth of LAC cells and xenografts in vitro and in vivo. Mechanistically, PTPN13 was identified as the direct target of miR-30e in LAC, in which PTPN13 expression was down-regulated in LAC tissues and showed the inverse correlation with miR-30e expression. Overexpression of PTPN13 inhibited cell growth and rescued the proliferation-promoting effect of miR-30e through inhibition of the EGFR signalling. Altogether, our findings suggest that miR-30e could function as an oncogene in LAC via targeting PTPN13 and act as a potential therapeutic target for treating LAC.
推荐引用方式
GB/T 7714：

Zhuang Li,Shou Tao,Li Ke, et al. MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma [J].JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,2017,21(11):2852-2862.
APA：

Zhuang Li,Shou Tao,Li Ke,Gao Chun-Lin,&Li Gao-Feng.(2017).MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE,21(11):2852-2862.
MLA：

Zhuang Li, et al. "MicroRNA-30e-5p promotes cell growth by targeting PTPN13 and indicates poor survival and recurrence in lung adenocarcinoma" .JOURNAL OF CELLULAR AND MOLECULAR MEDICINE 21,11(2017):2852-2862.
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