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Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers 期刊论文

编号：

a01e2fe3-b517-424f-b2cd-c4482494ad2c
作者：

Wen, Weihua#*^[1,2]Wen, Jinghua^[3];Lu, Lin^[1];Liu, Hua^[4];Yang, Jun^[1];Cheng, Huirong^[1];Che, Wangjun^[5];Li, Liang^[6];Zhang, Guanbei^[7];
语种：

英文
期刊：

TOXICOLOGY AND APPLIED PHARMACOLOGY ISSN：0041-008X 2011 年 254 卷 1 期 (41 - 47) ; JUL 1
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关键词：

Arsenic Monomethylarsonic acid Dimerhylarsinic acid Oxidative DNA damage P53 gene ROS
摘要：

Recent studies have shown that monomethylarsonous acid is more cytotoxic and genotoxic than arsenate and arsenite, which may attribute to the increased levels of reactive oxygen species. In this study, we used hydride generation-atomic absorption spectrometry to determine three arsenic species in urine of workers who had been working in arsenic plants,and calculated primary and secondary methylation indexes. The damages of exon 5, 6, 8 of p53 gene were determined by the method developed by Sikorsky, et al. Results show that the concentrations of each urinary arsenic species,and damage indexes of exon 5 and 8 of p53 gene in the exposed population were significantly higher, but SMI was significantly lower than in the control group. The closely positive correlation between the damage index of exon 5 and PMI,MMA, DMA were found, but there was closely negative correlation between the damage index of exon 5 and SMI. Those findings suggested that DNA damage of exon Sand 8 of p53 gene existed in the population occupationally exposed to arsenic. For exon 5, the important factors may include the model of arsenic metabolic transformation, the concentrations of MMA and DMA, and the MMA may be of great importance. (C) 2011 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Wen Weihua,Wen Jinghua,Lu Lin, et al. Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers [J].TOXICOLOGY AND APPLIED PHARMACOLOGY,2011,254(1):41-47.
APA：

Wen Weihua,Wen Jinghua,Lu Lin,Liu Hua,&Zhang Guanbei.(2011).Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers .TOXICOLOGY AND APPLIED PHARMACOLOGY,254(1):41-47.
MLA：

Wen Weihua, et al. "Metabolites of arsenic and increased DNA damage of p53 gene in arsenic plant workers" .TOXICOLOGY AND APPLIED PHARMACOLOGY 254,1(2011):41-47.
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