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HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway 期刊论文

编号：

a3086f0f-559b-4942-8c4d-7e51a4e097a0
作者：

Liu, Weijun#^[1]Zhang, Zhenyong#^[1]Zhang, Yongxue^[2];Chen, Xinju^[3];Guo, Shikui^[2];Lei, Yi^[2];Xu, Yu^[2];Ji, Chao^[4];Bi, Zhigang^[5];Wang, Kunhua*^[1,6]
语种：

英文
期刊：

CANCER BIOLOGY & THERAPY ISSN：1538-4047 2015 年 16 卷 4 期 (511 - 517) ; APR
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关键词：

apoptosis autophagy colorectal cancer HMGB1 MEK ERK pathway oxaliplatin
摘要：

In the present study, we examined the mechanisms of oxaliplatin-induced drug resistance in human colorectal cancer cell lines HT29 and HCT116. Our results demonstrate a significant autophagy expression in CRC cells after an oxaliplatin treatment. Administration of oxaliplatin to human CRC cells significantly enhanced the expression of HMGB1, which regulated the autophagy response and negatively regulate the cell apoptosis. Moreover, a decreased oxaliplatin -induced autophagy response and an increased apoptosis level were detected in stable CRC cells harboring HMGB1 shRNA. Then we noted that HMGB1 significantly induced extracellular signal-regulated kinase (ERK)/Extracellular signal-regulated kinase kinase (MEK) phosphorylation. Taken together, these data suggest that HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway.
推荐引用方式
GB/T 7714：

Liu Weijun,Zhang Zhenyong,Zhang Yongxue, et al. HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway [J].CANCER BIOLOGY & THERAPY,2015,16(4):511-517.
APA：

Liu Weijun,Zhang Zhenyong,Zhang Yongxue,Chen Xinju,&Wang Kunhua.(2015).HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway .CANCER BIOLOGY & THERAPY,16(4):511-517.
MLA：

Liu Weijun, et al. "HMGB1-mediated autophagy modulates sensitivity of colorectal cancer cells to oxaliplatin via MEK/ERK signaling pathway" .CANCER BIOLOGY & THERAPY 16,4(2015):511-517.
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