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GSTM1 and GSTT1 Genes are Associated With DNA Damage of p53 Gene in Coke-oven Workers 期刊论文

编号：

a7385b55-dc3e-456c-8e2c-658566dfc54d
作者：

He, Yuefeng(何越峰)#*; Qi, Jun;He, Fang;Zhang, Yongchang;Wang, Youlian;Zhang, Ruobing;Li, Gang*;
语种：

英文
期刊：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE ISSN：1076-2752 2017 年 59 卷 6 期 (499 - 501) ; JUN
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摘要：

Objectives:This study investigated whether variations in GSTT1 and GSTM1 gene are associated with the DNA damage level of p53 gene.Methods:We quantified urinary 1-hydroxypyrene using high-performance liquid chromatography, and examined the DNA damage level of p53 gene by real-time quantitative PCR in 756 coke-oven workers. Multiplex PCR was used to detect the presence or absence of genes.Results:DNA damage levels of p53 gene in the high exposure group and intermediate exposure group were significantly higher than that of p53 gene in the low exposure group (P<0.01). In coke-oven workers, the DNA damage levels of subjects with non-null genotype in GSTT1 or GSTM1 gene were significantly higher than that of those with the null genotype (P<0.01).Conclusions:GSTT1 and GSTM1 may modulate DNA damage levels of p53 gene when exposed to polycyclic aromatic hydrocarbons.
推荐引用方式
GB/T 7714：

He Yuefeng,Qi Jun,He Fang, et al. GSTM1 and GSTT1 Genes are Associated With DNA Damage of p53 Gene in Coke-oven Workers [J].JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,2017,59(6):499-501.
APA：

He Yuefeng,Qi Jun,He Fang,Zhang Yongchang,&Li Gang.(2017).GSTM1 and GSTT1 Genes are Associated With DNA Damage of p53 Gene in Coke-oven Workers .JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE,59(6):499-501.
MLA：

He Yuefeng, et al. "GSTM1 and GSTT1 Genes are Associated With DNA Damage of p53 Gene in Coke-oven Workers" .JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 59,6(2017):499-501.
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