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Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivatives as Analogs of Combretastatin A-4 期刊论文

编号：

a7c86fa0-9410-414c-b1cc-ecf1a0d11351
作者：

Jiang, KunMing#^[1]Dai, XiaoLi^[2];Li, Ke(李科)^[3]Wu, Di^[1];Zhang, JiHong^[2];Jin, Yi*^[1]Lin, Jun*^[1]
语种：

英文
期刊：

MEDICINAL CHEMISTRY ISSN：1573-4064 2015 年 11 卷 5 期 (453 - 461)
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关键词：

Cytotoxic activity (E)-N,2,3-triarylacrylamide SARs synthesis
摘要：

A new series of (E)-N,2,3-triarylacrylamide derivatives were designed and synthesized as potent anticancer agents. Cytotoxicity of the 26 target compounds was evaluated in vitro against six cancer cell lines (HCT116, A549, MDA-MB-468, HepG2, SKNMC and SK-OV-3) by Sulforhodamine B colorimetric assay. The most promising compound, 4h, was as potent as the reference drug cisplatin (DDP). Preliminary structure-activity relationship (SAR) data provided guidance for further design and discovery of (E)-N, 2,3-triarylacrylamide scaffold anticancer agents.
推荐引用方式
GB/T 7714：

Jiang Kun-Ming,Dai Xiao-Li,Li Ke, et al. Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivatives as Analogs of Combretastatin A-4 [J].MEDICINAL CHEMISTRY,2015,11(5):453-461.
APA：

Jiang Kun-Ming,Dai Xiao-Li,Li Ke,Wu Di,&Lin Jun.(2015).Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivatives as Analogs of Combretastatin A-4 .MEDICINAL CHEMISTRY,11(5):453-461.
MLA：

Jiang Kun-Ming, et al. "Synthesis and In-Vitro Cytotoxicity of (E)-N,2,3-Triarylacrylamide Derivatives as Analogs of Combretastatin A-4" .MEDICINAL CHEMISTRY 11,5(2015):453-461.
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