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Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory 期刊论文

编号：

aea0bec6-d2f3-4a78-87e7-f1effdddac29
作者：

Zhang, Xiaomin(张筱敏)#^[1,2]Yan, Xunyi^[1];Zhang, Bin^[1];Yang, Qian^[1];Ye, Mao^[1];Cao, Wei^[1];Qiang, Wenbin^[1];Zhu, Lijun^[1];Du, Yonglan^[1];Xu, Xingxing^[1];Wang, Jiasheng^[1];Xu, Fei^[1];Lu, Wei^[3];Qiu, Shuang*^[1]Yang, Wei*^[1]Luo, Jianhong*^[1]
语种：

英文
期刊：

CELL RESEARCH ISSN：1001-0602 2015 年 25 卷 7 期 (818 - 836) ; JUL
收录：
关键词：

NMDA receptors endoplasmic reticulum Bip non-canonical trafficking fear conditioning
摘要：

The N-methyl-D-aspartate receptor (NMDAR) in adult forebrain is a heterotetramer mainly composed of two GluN1 subunits and two GluN2A and/or GluN2B subunits. The synaptic expression and relative numbers of GluN2A-and GluN2B-containing NMDARs play critical roles in controlling Ca2+-dependent signaling and synaptic plasticity. Previous studies have suggested that the synaptic trafficking of NMDAR subtypes is differentially regulated, but the precise molecular mechanism is not yet clear. In this study, we demonstrated that Bip, an endoplasmic reticulum (ER) chaperone, selectively interacted with GluN2A and mediated the neuronal activity-induced assembly and synaptic incorporation of the GluN2A-containing NMDAR from dendritic ER. Furthermore, the GluN2A-specific synaptic trafficking was effectively disrupted by peptides interrupting the interaction between Bip and GluN2A. Interestingly, fear conditioning in mice was disrupted by intraperitoneal injection of the interfering peptide before training. In summary, we have uncovered a novel mechanism for the activity-dependent supply of synaptic GluN2A-containing NMDARs, and demonstrated its relevance to memory formation.
推荐引用方式
GB/T 7714：

Zhang Xiao-min,Yan Xun-yi,Zhang Bin, et al. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory [J].CELL RESEARCH,2015,25(7):818-836.
APA：

Zhang Xiao-min,Yan Xun-yi,Zhang Bin,Yang Qian,&Luo Jian-hong.(2015).Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory .CELL RESEARCH,25(7):818-836.
MLA：

Zhang Xiao-min, et al. "Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory" .CELL RESEARCH 25,7(2015):818-836.
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