Successful drug treatment for sepsis-related acute lung injury (ALI) remains a major clinical problem. Thus, the aim of the present study was to investigate the beneficial effects of salidroside on ameliorating cecal ligation and puncture (CLP)-induced lung inflammation. Rats underwent CLP surgery to induce ALI and 800 mg/kg salidroside (i.v.) was administered 24 h after the CLP challenge. Subsequently, biochemical changes in the blood and lung tissues, as well as morphological and histological alterations in the lungs, that were associated with inflammation and injury were analysed. CLP was shown to significantly increase the serum levels of plasma tumour necrosis factor-a and interleukin-6, -1 beta and-10. In addition, CLP increased pulmonary oedema, thickened the alveolar septa and caused inflammation in the lung cells. These changes were ameliorated by the administration of 800 mg/kg salidroside (i.v.) 24 h after the CLP challenge. This post-treatment drug administration also significantly attenuated the lipopolysaccharide-induced activation of nuclear factor-kappa beta and increased the release of peroxisome proliferator-activated receptor gamma in the lung tissue. Therefore, salidroside administered following the induction of ALT by CLP significantly prevented and reversed lung tissue injuries. The positive post-treatment effects of salidroside administration indicated that salidroside may be a potential candidate for the management of lung inflammation in CLP-induced endotoxemia and septic shock.
[1]Kunming Med Univ, Affiliated Hosp 1, Dept Emergency, Kunming 650032, Yunnan, Peoples R China.
[2]Kunming Med Univ, Affiliated Hosp 2, Surg Intens Care Unit, Kunming 650106, Yunnan, Peoples R China.
[3]Kunming Med Univ, Yanan Hosp, Dept Infect Dis, Kunming 650051, Yunnan, Peoples R China.
(8.0+极速模式)