首页 / 院系成果 / 成果详情页

The MDM2 309 T/G Polymorphism is Associated with Head and Neck Cancer Risk Especially in Nasopharyngeal Cancer: A Meta-Analysis  期刊论文  

  • 编号:
    be1eb257-082d-43e1-9227-71d5bea69e49
  • 作者:
    Zhang, Yaowei#[1]Bai, Yang[2];Zhang, Yong[3];Guan, Jian[1];Chen, Longhua*[1]
  • 语种:
    英文
  • 期刊:
    ONKOLOGIE ISSN:0378-584X 2012 年 35 卷 11 期 (666 - 670) ; NOV
  • 收录:
  • 关键词:
  • 摘要:

    Background: Published data on the association between mouse double minute 2 (MDM2) 309 T/G single nucleotide polymorphism (SNP) and head and neck cancer (HNC) risk are inconclusive. To derive a more precise estimation of the relationship, we performed a meta-analysis. Material and Methods: A systematic computerized search of PubMed was performed. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between the polymorphism and HNC risk. The pooled ORs were performed for TT versus GG, TG versus GG, dominant model (TT+TG vs. GG) and recessive model (TT vs. TG+GG), respectively. Results: A total of 9 studies including 2,755 cases and 4,121 controls were involved in the final meta-analysis. The results of the overall meta-analysis provided some evidence of an association between the polymorphism and HNC risk (OR = 0.82, 95% CI 0.67-0.99 for TG vs. GG). In the subgroup meta-analysis based on the types of tumor, we detected a significantly decreased NPC risk for all genetic models. Conclusion: This meta-analysis suggests that the GG genotype of MDM2 SNP309 is associated with HNC risk. The MDM2 SNP309G allele is a highly penetrant risk factor for developing NPC.

  • 推荐引用方式
    GB/T 7714:
    Zhang Yaowei,Bai Yang,Zhang Yong, et al. The MDM2 309 T/G Polymorphism is Associated with Head and Neck Cancer Risk Especially in Nasopharyngeal Cancer: A Meta-Analysis [J].ONKOLOGIE,2012,35(11):666-670.
  • APA:
    Zhang Yaowei,Bai Yang,Zhang Yong,Guan Jian,&Chen Longhua.(2012).The MDM2 309 T/G Polymorphism is Associated with Head and Neck Cancer Risk Especially in Nasopharyngeal Cancer: A Meta-Analysis .ONKOLOGIE,35(11):666-670.
  • MLA:
    Zhang Yaowei, et al. "The MDM2 309 T/G Polymorphism is Associated with Head and Neck Cancer Risk Especially in Nasopharyngeal Cancer: A Meta-Analysis" .ONKOLOGIE 35,11(2012):666-670.
  • 条目包含文件:
    文件类型:PDF,文件大小:
    正在加载全文
浏览次数:48 下载次数:0
浏览次数:48
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部