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The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5 期刊论文

编号：

c4eb2f49-408a-4aa9-8af4-b9f0cca2caae
作者：

Wang, Hui(王辉)#^[1]Dong, Xiaolin#^[2]Gu, Xin^[3];Qin, Rong(秦榕)^[1]Jia, Hongping^[1];Gao, Jianpeng(高建鹏)*^[1]
语种：

英文
期刊：

PLOS ONE ISSN：1932-6203 2015 年 10 卷 6 期 ; JUN 22
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摘要：

Gastric cancer (GC) is one of the most common malignancies worldwide. Emerging evidence has shown that aberrant expression of microRNAs (miRNAs) plays important roles in cancer progression. However, little is known about the potential role of miR-217 in GC. In this study, we investigated the role of miR-217 on GC cell proliferation and invasion. The expression of miR-217 was down-regulated in GC cells and human GC tissues. Enforced expression of miR-217 inhibited GC cells proliferation and invasion. Moreover, Glypican-5 (GPC5), a new ocncogene, was identified as the potential target of miR-217. In addition, overexpression of miR-217 impaired GPC5-induced promotion of proliferation and invasion in GC cells. In conclusion, these findings revealed that miR-217 functioned as a tumor suppressor and inhibited the proliferation and invasion of GC cells by targeting GPC5, which might consequently serve as a therapeutic target for GC patients.
推荐引用方式
GB/T 7714：

Wang Hui,Dong Xiaolin,Gu Xin, et al. The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5 [J].PLOS ONE,2015,10(6).
APA：

Wang Hui,Dong Xiaolin,Gu Xin,Qin Rong,&Gao Jianpeng.(2015).The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5 .PLOS ONE,10(6).
MLA：

Wang Hui, et al. "The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5" .PLOS ONE 10,6(2015).
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