Somatostatinoma is a rare pancreatic tumor characterized by diabetes mellitus, cholelithiases, and diarrhea. Although hypoglycemia is a distinctively unusual manifestation of the condition, most patients are symptomatic at the time of diagnosis. However, since the tumor is slow growing and symptoms are often not present for several years before diagnosis, the disease is often quite advanced by the time, patients seek medical attention and preoperative diagnosis is therefore often difficult. We reported a 30-year-old man who presented with hypoglycemia, hypersomnia and hyperinsulinemia. Magnetic resonance imaging (MRI) demonstrated a low-density mass in the head of the pancreas suggestive of a malignancy that was definitively identified as a somatostatinoma by immunohistochemical staining of a biopsy specimen.
[1]Kunming Med Univ, Qujing Affiliated Hosp, Dept Endocrinol & Rheumatol, Kunming 655000, Yunnan, Peoples R China.
[2]Kunming Med Univ, Qujing Affiliated Hosp, Dept MRI, Kunming 655000, Yunnan, Peoples R China.
[3]Kunming Med Univ, Qujing Affiliated Hosp, Dept Pathol, Kunming 655000, Yunnan, Peoples R China.
[4]Kunming Med Univ, Qujing Affiliated Hosp, Dept Workstn Academicians & Experts Yunnan Prov, Kunming 655000, Yunnan, Peoples R China.
[5]Second Peoples Hosp Qujing, Dept Hepatobiliary Surg, Qujing 655000, Yunnan, Peoples R China.
[6]Georgetown Univ, Med Ctr, Dept Pediat & Microbiol Immunol, Washington, DC 20007 USA.
[7]Penn State Univ, Div Rheumatol, Coll Med, 500 Univ Dr, Hershey, PA 17033 USA.
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