首页 / 院系成果 / 成果详情页

Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung  期刊论文  

  • 编号:
    dfae3004-d71e-4277-8189-ec67c192f00b
  • 作者:
    Tai, Wenlin(邰文琳)#[1]Xu, Yiheng(徐益恒)#[1]Ding, Jiawei[1];Wu, Hanxin[1];Du, Ming[1];Qu, Xiaoyuan[1];Gao, Ling[1];Li, Jinyu(李劲榆)*[1]Dong, Zhaoxing(董昭兴)*[2]
  • 语种:
    英文
  • 期刊:
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY ISSN:1015-8987 2017 年 44 卷 4 期 (1526 - 1536)
  • 收录:
  • 关键词:
  • 摘要:

    Background/Aims: Acute lung injury (ALI) remains a severe disease that threatens human life around the world. To decrease the mortality of ALI and improve ALI treatment efficacy, the development of more ALI treatments is urgently needed. Whether fibrocytes directly participate in ALI has not been studied. Therefore, a mouse model of ALI was induced with lipopolysaccharide (LPS). Methods: Fibrocytes were harvested from peripheral blood mononuclear cells of bleomycin mice and identified by using flow cytometry to detect the expression of molecular makers. The fibrocytes were injected for the treatment of acute lung injury mice. The curative effects were evaluated by using ELISA to determine the cytokines (including TNF-alpha, IL-6 and IFN-gamma) concentrations in bronchoalveolar lavage fluid (BALF) supernatant. Results: The concentrations of cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interferon-gamma (IFN-gamma) were increased in mice with ALI induced with LPS. The concentrations of TNF-alpha, IL-6, and IFN-gamma as well as their mRNA and protein expression levels were decreased by administration of fibrocytes. The effect of fibrocytes in ameliorating ALI was time dependent. LPS treatment induced an increase in myeloperoxidase (MPO) activity, whereas the fibrocyte treatment caused inhibition of MPO activity as well as expression of the neutrophil-chemoattractant chemokine macrophage inflammatory protein 2 (MIP-2). Conclusion: Taken together, these data suggest that fibrocytes ameliorated ALI by suppressing inflammatory cytokines and chemokines as well as by decreasing the accumulation of neutrophils in the lung. (C) 2017 The Author(s) Published by S. Karger AG, Basel

  • 推荐引用方式
    GB/T 7714:
    Tai Wenlin,Xu Yiheng,Ding Jiawei, et al. Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung [J].CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2017,44(4):1526-1536.
  • APA:
    Tai Wenlin,Xu Yiheng,Ding Jiawei,Wu Hanxin,&Dong Zhaoxing.(2017).Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,44(4):1526-1536.
  • MLA:
    Tai Wenlin, et al. "Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung" .CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 44,4(2017):1526-1536.
  • 条目包含文件:
    文件类型:PDF,文件大小:
    正在加载全文
浏览次数:127 下载次数:0
浏览次数:127
下载次数:0
打印次数:0
浏览器支持: Google Chrome   火狐   360浏览器极速模式(8.0+极速模式) 
返回顶部