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Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata 期刊论文

编号：

e87e6aa1-06f0-4543-8bee-9734146dc902
作者：

Liu, Xiuhong[0];Liu, Rui[1];Wei, Lin[2];Yang, Hailong[3];Zhang, Keyun[4];Liu, Jingze[5];Lai, Ren[6];
地址：

Nanjing Agricultural University, Life Sciences College,Nanjing,China[0];Kunming Institute of Zoology Chinese Academy of Sciences, Key Laboratory of Animal Models and Human Disease Mechanisms,Kunming,China[1];Shandong University, School of Physics and Microelectronics,Jinan,China[2];Kunming Medical University, School of Basic Medical Sciences,Kunming,China[3];Nanjing Agricultural University, Department of Zoology,Nanjing,China[4];Hebei Normal University, College of Life Sciences,Shijiazhuang,China[5];Chinese Academy of Sciences, Sino-African Joint Research Center,Beijing,China[6];
Scopus被引频次：

4 次
语种：

英文
期刊：

Journal of Peptide Science ISSN：1075-2617 2011 年 17 卷 1 期 (68 - 72)
收录：
关键词：

Amphibian Antimicrobial peptides Brevinin-2 Rana nigrovittata Skin
摘要：

Two novel antimicrobial peptides with similarity to brevinin-2 family are purified and characterized from the skin secretions of the frog, Rana nigrovittata. Their amino acid sequences were determined as GAFGNFLKGVAKKAGLKILSIAQCKLSGTC (brevinin-2-RN1) and GAFGNFLKGVAKKAGLKILSIAQCKLFGTC (brevinin-2-RN2), respectively, by Edman degradation. Different from brevinin-2, which is composed of 33 amino acid residues (aa), both brevinin-2-RN1 and -RN2 contain 30 aa. Five cDNA sequences (Genbank accession numbers, EU136465-9) encoding precursors of brevinin-2-RN1 and -RN2 were screened from the skin cDNA library of R. nigrovittata. These precursors are composed of 72 aa including a predicted signal peptide, an acidic spacer peptide, and a mature brevinin-2-RN. Both brevinin-2-RN1 and -RN2 showed strong antimicrobial activities against gram-positive and gram-negative bacteria and fungi. The current work identified and characterized two novel antimicrobial peptides with unique primary structure. ? 2010 European Peptide Society and John Wiley & Sons, Ltd.
推荐引用方式
GB/T 7714：

Liu Xiuhong[0],Liu Rui[1],Wei Lin[2], et al. Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata [J].Journal of Peptide Science,2011,17(1):68-72.
APA：

Liu Xiuhong[0],Liu Rui[1],Wei Lin[2],Yang Hailong[3],&Lai Ren[6].(2011).Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata .Journal of Peptide Science,17(1):68-72.
MLA：

Liu Xiuhong[0], et al. "Two novel antimicrobial peptides from skin secretions of the frog, Rana nigrovittata" .Journal of Peptide Science 17,1(2011):68-72.

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