Mild traumatic brain injury (mTBI) potentially causes long-lasting cognitive deficits, emotional difficulties and behavioral disturbances. Owing to a lack of observable damages following mTBI, the early diagnosis and long-term impact of the insult are limited. In the present study, we assessed the effects of singular and repetitive experimental mTBI (smTBI and rmTBI) in rats on the cognitive, motor function and anxiety-like behavior as well as the time-point changes of BDNF and Nogo-A within 24 days following injuries. Experimental brain injury was induced using a concussive head trauma with a weight-drop device. The single and repetitive mTBI injured rats and sham-operated rats were tested for cognitive, motor function and anxiety-like behavior at 1, 7 and 14 days post-trauma. The results showed that smTBI rats showed impaired cognitive, motor function and anxiety-like behavior within one week after injuries. rmTBI resulted in motor functional impairment of rats within one week while the cognitive deficits and anxiety behavior lasted until two weeks after the injury. Furthermore, brain BDNF peaked at day 2 in smTBI hippocampus CA1 sections and at day 4 for rmTBI rats. Meanwhile, the hippocampus Nogo-A significantly decreased at day 4 in smTBI rats and at day 8 for rmTBI rats. Likewise, BDNF and Nogo-A fluctuated at each time point tested in secondary motor cortex M2-1 of the rat post-smTBI and rmTBI. In conclusion, the time-course change of BDNF and Nogo-A might provide clues for the early diagnosis and treatment of single and repetitive mild TBI.
[1]Kunming Med Univ, Sch Forens Med, 1168 Chunrong Western Rd, Kunming 650500, Yunnan, Peoples R China.
[2]Kunming Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Kunming, Yunnan, Peoples R China.
[3]Chongqing Municipal Publ Secur Bur, Yuzhong Dist Subbur, Mat Evidence Identificat Ctr, Chongqing, Peoples R China.
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