Ten previously undescribed cassane diterpenoids, cassabonducins A-J, and eleven known compounds were isolated from the seeds of Caesalpinia bonduc. The structures of the undescribed compounds were elucidated by extensive analysis of spectroscopic data (IR, HRESIMS, and H-1, C-13 and 2D NMR) and their absolute configurations were determined by the ECD data and single-crystal X-ray diffraction analysis. epsilon-Caesalpin-VII was obtained from natural resources for the first time. Cassabonducin A possessed noteworthy inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 6.12 mu M. Cassabonducin D and neocaesalpin N showed moderate alpha-glucosidase inhibition at the concentration of 50 mu M with inhibitory capacities of 47.17% and 43.83%, respectively.
[1]Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China.
[2]Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China.
[3]Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China.
[4]Yunnan Minzu Univ, Key Lab Ethn Med Resource Chem, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China.
[5]Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China.
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