Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were retrospectively identified from 2005 to 2019 by 27 centers in China. For each case, 2 controls matched by the time of ITP diagnosis and the duration of ITP were provided by the same center. Multivariate analysis identified head trauma (OR = 3.216, 95%CI 1.296-7.979,P=.012), a platelet count <= 15,000/mu L at the time of ITP diagnosis (OR = 1.679, 95%CI 1.044-2.698,P=.032) and severe/life-threatening bleeding (severe bleedingvs. mild bleeding, OR = 1.910, 95%CI 1.088-3.353,P=.024; life-threatening bleedingvs. mild bleeding, OR = 2.620, 95%CI 1.360-5.051,P=.004) as independent risk factors for ICH. Intraparenchymal hemorrhage (OR = 5.191, 95%CI 1.717-15.692,P=.004) and a history of severe bleeding (OR = 4.322, 95%CI 1.532-12.198,P=.006) were associated with the 30-day outcome of ICH. These findings may facilitate ICH risk stratification and outcome prediction in patients with ITP.
[1]Peking Univ, Peoples Hosp, Inst Hematol, Beijing, Peoples R China.
[2]Natl Clin Res Ctr Hematol Dis, Beijing, Peoples R China.
[3]Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China.
[4]Peking Univ, Collaborat Innovat Ctr Hematol, Beijing, Peoples R China.
[5]Shandong Univ, Qilu Hosp, Dept Hematol, Jinan, Peoples R China.
[6]Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Hematol, Beijing, Peoples R China.
[7]Peking Univ, Dept Clin Epidemiol, Peoples Hosp, Beijing, Peoples R China.
[8]Nanchang Univ, Dept Hematol, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China.
[9]Hainan Gen Hosp, Dept Hematol, Haikou, Hainan, Peoples R China.
[10]Sichuan Univ, West China Hosp, Dept Hemotol, Chengdu, Peoples R China.
[11]Xinjiang Med Univ, Dept Hematol, Affiliated Hosp 1, Urumqi, Peoples R China.
[12]Inner Mongolia Med Univ, Dept Hematol, Affiliated Hosp, Hohhot, Peoples R China.
[13]Fujian Med Univ, Fujian Inst Hematol, Union Hosp, Fuzhou, Peoples R China.
[14]Zhengzhou Univ, Dept Hematol, Affiliated Canc Hosp, Zhengzhou, Peoples R China.
[15]Kunming Med Univ, Dept Hematol, Affiliated Hosp 2, Kunming, Yunnan, Peoples R China.
[16]First Hosp Jilin Univ, Dept Hematol, Changchun, Peoples R China.
[17]Lanzhou Univ, Dept Hematol, Hosp 2, Lanzhou, Peoples R China.
[18]Shandong Univ, Dept Hematol, Shandong Prov Hosp, Jinan, Peoples R China.
[19]Tianjin Med Univ Gen Hosp, Dept Hematol, Tianjin, Peoples R China.
[20]Minist Hlth, Dept Hematol, Beijing Hosp, Beijing, Peoples R China.
[21]Shanxi Med Univ, Dept Hematol, Affiliated Hosp 2, Taiyuan, Peoples R China.
[22]Shanxi Med Univ, Dept Hematol, Affiliated Shanxi Big Hosp, Taiyuan, Peoples R China.
[23]Guangzhou First Peoples Hosp, Dept Hematol, Guangzhou, Peoples R China.
[24]Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China.
[25]Peking Univ, Dept Hematol, Hosp 1, Beijing, Peoples R China.
[26]Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Shanghai, Peoples R China.
[27]Nanfang Med Univ, Nanfang Hosp, Guangzhou, Peoples R China.
[28]Capital Med Univ, Beijing Luhe Hosp, Beijing, Peoples R China.
[29]Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Hematol, Beijing, Peoples R China.
[30]Capital Med Univ, Fuxing Hosp, Beijing, Peoples R China.
[31]Hebei Med Univ, Dept Hematol, Hosp 2, Shijiazhuang, Hebei, Peoples R China.
[32]Chinese Acad Sci, Collaborat Innovat Ctr Genet & Dev, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing, Peoples R China.
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