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Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer 期刊论文

编号：

2B3A3784D940B6A801BAD3A4E1B239B9
作者：

Zhao, Ping(赵平)#^[1]Sun, Jian#^[1]Huang, Xinwei(黄新伟)#^[2]Zhang, Xiangwu^[1];Liu, Xin^[1];Liu, Rong(刘蓉)^[3]Du, Guangshi^[4];Gan, Wenqiang^[5,6];Yang, Chuanyu^[5];Tang, Yiyin(唐一吟)*^[1]Chen, Ceshi(陈策实)*^[1,5,7]Jiang, Dewei(蒋德伟)*^[5,6]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES ISSN：1449-2288 2023 年 19 卷 6 期 (1861 - 1874)
收录：
关键词：

EphA2 TNF-? KLF5 BLBC stem cells Chemoresistance ALW-II-41-27
摘要：

Ephrin type-A receptor 2 (EphA2) is a member of the tyrosine receptor kinases, a family of membrane proteins recognized as potential anticancer targets. EphA2 highly expressed in a variety of human cancers, playing roles in proliferation, migration, and invasion. However, whether and how EphA2 regulates basal-like breast cancer (BLBC) cell stemness and chemoresistance has not been revealed. Here, KLF5 was proven to be a direct transcription factor for EphA2 in BLBC cells, and its expression was positively correlated in clinical samples from breast cancer patients. The inflammatory factor TNF-alpha could promote BLBC cell stemness partially by activating the KLF5-EphA2 axis. Moreover, phosphorylation of EphA2 at S897 (EphA2 pS897) induced by TNF-alpha and PTX/DDP contributes to chemoresistance of BLBC. Furthermore, the EphA2 inhibitor ALW-II-41-27 could effectively reduce EphA2 pS897 and tumor cell stemness in vitro and significantly enhance the sensitivity of xenografts to the chemotherapeutic drugs PTX and DDP in vivo. Clinically, tumor samples from breast patients with less response to neoadjuvant chemotherapy showed a high level of EphA2 pS897 expression. In conclusion, KLF5-EphA2 promotes stemness and drug resistance in BLBC and could be a potential target for the treatment of BLBC.
推荐引用方式
GB/T 7714：

Zhao Ping,Sun Jian,Huang Xinwei, et al. Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer [J].INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,2023,19(6):1861-1874.
APA：

Zhao Ping,Sun Jian,Huang Xinwei,Zhang Xiangwu,&Jiang Dewei.(2023).Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,19(6):1861-1874.
MLA：

Zhao Ping, et al. "Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer" .INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 19,6(2023):1861-1874.
入库时间：

2023/5/20 21:50:14
更新时间：

2023/5/20 21:50:14
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