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Dual-target tDCS and dual-task training modulate neuroinflammation and neuroplasticity: transcriptomic and behavioral evidence in stroke rehabilitation 期刊论文

编号：

3CBDE3EDF78660671C6BAC88EE1F6D15
作者：

Fu, Yutong(付雨桐)#^[1]Yan, Qianxi^[1];Wang, Anjuan^[1];Zhang, Hongmei(张红梅)*^[1]Wang, Wenli(王文丽)*^[1]Yao, Liqing(姚黎清)*^[1]
语种：

英文
期刊：

FRONTIERS IN REHABILITATION SCIENCES ISSN：2673-6861 2025 年 6 卷 ; OCT 17
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关键词：

tDCS dual-task training neurorehabilitation transcriptomics inflammation neuroplasticity
摘要：

Background Transcranial direct current stimulation (tDCS) combined with dual-task training (DTT) has shown potential in promoting neurorehabilitation. However, the transcriptomic mechanisms underlying the synergistic effects of dual-target tDCS remain unexplored. This study aims to evaluate the effects of tDCS + DTT on cognitive and motor functions and preliminarily explore its molecular basis through transcriptomic analysis.Methods Fifty two chronic stroke patients were randomized to receive dual-target tDCS (anodal electrodes over affected primary motor cortex M1 and left dorsolateral prefrontal cortex DLPFC) combined with DTT (n = 26) or sham stimulation with DTT (n = 26). Behavioral assessments, including the Visual Cognitive Assessment Test (VCAT), Hamilton Depression Scale (HAMD), Fugl-Meyer Lower Limb Assessment (FMA-L), Timed Up and Go Test (TUG), and Modified Barthel Index (MBI), were conducted before and after the intervention. Peripheral blood transcriptomic analysis was performed on a subset of patients from the tDCS + DTT group to identify differentially expressed genes (DEGs) and enriched pathways.Results Significant interactions were observed for VCAT (p < 0.001), MBI (p = 0.033), HAMD (p < 0.001), FM-L (p < 0.001), TUG-CMDT time (p < 0.001), and TUG-CMDT accuracy rate (p < 0.001). Transcriptomic analysis revealed 1,319 DEGs post-treatment, predominantly downregulating inflammation/apoptosis-related genes (1,155) and upregulating neuroplasticity-associated genes (164). KEGG pathway analysis highlighted suppressed NF-kappa B signaling and apoptosis pathways, alongside enhanced synaptic plasticity mechanisms. Key regulatory genes, such as PPP1R15A, BCL3, GADD45B, and NFKBIA, were identified as potential mediators of tDCS-induced neuroprotection.Conclusion Dual-target tDCS combined with DTT promotes functional recovery in stroke patients through transcriptomic reprogramming of inflammatory and neuroplastic pathways, offering a novel strategy for multi-modal neurorehabilitation.
推荐引用方式
GB/T 7714：

Fu Yutong,Yan Qianxi,Wang Anjuan, et al. Dual-target tDCS and dual-task training modulate neuroinflammation and neuroplasticity: transcriptomic and behavioral evidence in stroke rehabilitation [J].FRONTIERS IN REHABILITATION SCIENCES,2025,6.
APA：

Fu Yutong,Yan Qianxi,Wang Anjuan,Zhang Hongmei,&Yao Liqing.(2025).Dual-target tDCS and dual-task training modulate neuroinflammation and neuroplasticity: transcriptomic and behavioral evidence in stroke rehabilitation .FRONTIERS IN REHABILITATION SCIENCES,6.
MLA：

Fu Yutong, et al. "Dual-target tDCS and dual-task training modulate neuroinflammation and neuroplasticity: transcriptomic and behavioral evidence in stroke rehabilitation" .FRONTIERS IN REHABILITATION SCIENCES 6(2025).
入库时间：

2025/11/23 21:30:28
更新时间：

2025/11/23 21:30:28
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