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The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia 期刊论文

编号：

420C18F55F88220BC08FF8A0A50A5D44
作者：

Tang, Jiapeng#^[1]Chen, Ye#^[1]Sun, Mengting^[1];Luo, Manjun^[1];Chen, Yige^[1,2];Chen, Kebin^[1];Zou, Qi^[1];Peng, Yuan^[1];Wang, Tingting*^[1]Qin, Jiabi(秦家碧)*^[3]
语种：

英文
期刊：

JOURNAL OF LIPID RESEARCH ISSN：0022-2275 2025 年 66 卷 12 期 ; DEC
收录：
关键词：

gestational diabetes mellitus preeclampsia lipid profiles lipid-derived indicators cohort early pregnancy
摘要：

The relationship between early pregnancy lipid indicators and gestational diabetes mellitus (GDM) or pre-eclampsia (PE) remains incompletely elucidated. This prospective cohort study explored the associations between seven lipid indicators and GDM and PE among 32,411 pregnant participants. The results suggested that triglycerides (TGs), total cholesterols (TCs), and remnant cholesterols (RCs) were positively associated with both GDM and the composite outcome (GDM/PE). For GDM, compared with the lowest quartile, the highest quartile had odds ratios (ORs) of 1.646 (95% confidence interval [95% CI]: 1.363, 1.988) for TGs, 1.654 (95% CI: 1.241, 2.205) for TCs, and 1.396 (95% CI: 1.189, 1.640) for RCs. For GDM/PE, the corresponding ORs in the highest versus lowest quartile were 1.564 (95% CI: 1.302, 1.877) for TGs, 1.655 (95% CI: 1.253, 2.186) for TCs, and 1.379 (95% CI: 1.180, 1.612) for RCs. Non-HDL-C showed a negative association with GDM and GDM/PE, with ORs of 0.833 (95% CI: 0.758, 0.916) and 0.871 (95% CI: 0.795, 0.954), respectively. TG/HDL-C ratio was positively associated with PE, with an OR of 2.451 (95% CI: 1.369, 4.388). The OR values of the second and third quantiles of HDL-C for PE were 1.706 (95% CI: 1.301, 2.238) and 1.598 (95% CI: 1.170, 2.183), respectively. Nonlinear dose-response relationships were observed for most lipids with the outcomes. Additionally, early pregnancy TG, RC, and TG/HDL-C ratio partially mediated the effect of maternal age on all three outcomes (mediated proportion 2-7%). Non-HDL-C mediated the age-PE pathway (1%). This study simultaneously included multiple lipid parameters for systematic analysis, revealing the impact of dyslipidemia on pregnancy outcomes from a more comprehensive perspective and providing richer evidence for exploring related mechanisms and clinical assessment.
推荐引用方式
GB/T 7714：

Tang Jiapeng,Chen Ye,Sun Mengting, et al. The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia [J].JOURNAL OF LIPID RESEARCH,2025,66(12).
APA：

Tang Jiapeng,Chen Ye,Sun Mengting,Luo Manjun,&Qin Jiabi.(2025).The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia .JOURNAL OF LIPID RESEARCH,66(12).
MLA：

Tang Jiapeng, et al. "The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia" .JOURNAL OF LIPID RESEARCH 66,12(2025).
入库时间：

2026/1/8 21:58:30
更新时间：

2026/1/26 23:29:42

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