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Chemodynamic Therapy of Oral Squamous Cell Carcinoma 期刊论文

编号：

5147E497821C4F9A8CB0E2C6FABD255A
作者：

Wang, Lidong#^[1,2,3]Sun, Yongyan^[4];Sun, Yuting^[4];Zhang, Changbin(张长彬)^[1,2,3]Wang, Guixi^[5];He, Junnan*^[4]Zhao, Yan*^[4]Li, Ming(黎明)*^[1,2,3]
语种：

英文
期刊：

ACS APPLIED MATERIALS & INTERFACES ISSN：1944-8244 2026 年 18 卷 9 期 (13649 - 13669) ; MAR 11
收录：
关键词：

GSH-activated nanoplatform photodynamic/chemodynamic therapy fluorescence imaging-guided therapy oral squamous cell carcinoma nanozyme-enhanced therapy
摘要：

Photodynamic therapy (PDT) holds promise for oral squamous cell carcinoma (OSCC) but is limited by the tumor microenvironment-specifically hypoxia, elevated glutathione (GSH), and the lack of tumor-selective photosensitizer activation. To overcome these barriers, we developed a GSH-activated nanoplatform Cu-TCPP(Zn)/Ti3C2Tx for fluorescence imaging-guided synergistic photodynamic/chemodynamic therapy (PDT/CDT). The system is constructed from two-dimensional Cu-TCPP(Zn) MOF nanosheets, where Cu2+ and Zn2+ completely quench the fluorescence and PDT activity of TCPP and surface-anchored Ti3C2Tx MXene. In the TME, overexpressed GSH reduces Cu2+ to Cu+ and abstracts Zn from the Zn-N-4 complex, triggering nanocomposite disintegration to restore fluorescence, activate PDT, and simultaneously deplete GSH to reduce antioxidant defense. The resulting Cu+ catalyzes a Fenton-like reaction with endogenous H2O2 to generate center dot OH for CDT, while Ti3C2Tx acts as a catalase-like nanozyme, decomposing H2O2 into O-2 to alleviate hypoxia, promote charge transfer, improve the utilization efficiency of photogenerated electrons, and enhance PDT efficacy. In vitro, the platform showed excellent biocompatibility and GSH-responsive activation, inducing 41.21% apoptosis in CAL-27 cells under 660 nm laser irradiation, significantly outperforming controls. In vivo, the nanocomposite accumulated efficiently in tumors via the EPR effect, suppressed tumor growth, and exhibited no observable systemic toxicity. This work provides a TME-responsive theranostic platform that integrates tumor-specific activation, GSH depletion, hypoxia alleviation, and enhanced ROS generation for precise and effective OSCC treatment.
推荐引用方式
GB/T 7714：

Wang Lidong,Sun Yongyan,Sun Yuting, et al. GSH-Activated Cu-TCPP(Zn)/Ti3C2Tx Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma [J].ACS APPLIED MATERIALS & INTERFACES,2026,18(9):13649-13669.
APA：

Wang Lidong,Sun Yongyan,Sun Yuting,Zhang Changbin,&Li Ming.(2026).GSH-Activated Cu-TCPP(Zn)/Ti3C2Tx Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma .ACS APPLIED MATERIALS & INTERFACES,18(9):13649-13669.
MLA：

Wang Lidong, et al. "GSH-Activated Cu-TCPP(Zn)/Ti3C2Tx Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma" .ACS APPLIED MATERIALS & INTERFACES 18,9(2026):13649-13669.
入库时间：

2026/3/31 22:15:11
更新时间：

2026/4/16 1:58:38
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