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A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes 期刊论文

编号：

52680DDDDEE4DD7F06A7D115712F822A
作者：

Zhang, Liming#^[1,2,3]Wang, Daxi#^[4]Shi, Peibo^[4,5];Li, Juzhen^[1];Niu, Jichen^[1];Chen, Jielong^[1];Wang, Gang^[1];Wu, Linjuan^[1];Chen, Lu^[1];Yang, Zhenxing^[6];Li, Susheng^[6];Meng, Jinxin^[6];Ruan, Fangchao^[7];He, Yuwen^[6];Zhao, Hailong^[4];Ren, Zirui^[4];Wang, Yibaina^[8];Liu, Yang^[2];Shi, Xiaolu^[3];Wang, Yunfu^[9];Liu, Qiyong(刘起勇)^[10]Li, Junhua(李俊桦)^[4]Wang, Penghua^[11]Wang, Jinglin(王静林)*^[6]Zhu, Yibin(朱毅斌)*^[1,3]Cheng, Gong(程功)*^[1,2,3,12]
语种：

英文
期刊：

SCIENCE ISSN：0036-8075 2024 年 384 卷 6693 期 ; APR 19
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摘要：

The commensal microbiota of the mosquito gut plays a complex role in determining the vector competence for arboviruses. In this study, we identified a bacterium from the gut of field Aedes albopictus mosquitoes named Rosenbergiella sp. YN46 (Rosenbergiella_YN46) that rendered mosquitoes refractory to infection with dengue and Zika viruses. Inoculation of 1.6 x 10(3) colony forming units (CFUs) of Rosenbergiella_YN46 into A. albopictus mosquitoes effectively prevents viral infection. Mechanistically, this bacterium secretes glucose dehydrogenase (RyGDH), which acidifies the gut lumen of fed mosquitoes, causing irreversible conformational changes in the flavivirus envelope protein that prevent viral entry into cells. In semifield conditions, Rosenbergiella_YN46 exhibits effective transstadial transmission in field mosquitoes, which blocks transmission of dengue virus by newly emerged adult mosquitoes. The prevalence of Rosenbergiella_YN46 is greater in mosquitoes from low-dengue areas (52.9 to similar to 91.7%) than in those from dengue-endemic regions (0 to similar to 6.7%). Rosenbergiella_YN46 may offer an effective and safe lead for flavivirus biocontrol.
推荐引用方式
GB/T 7714：

Zhang Liming,Wang Daxi,Shi Peibo, et al. A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes [J].SCIENCE,2024,384(6693).
APA：

Zhang Liming,Wang Daxi,Shi Peibo,Li Juzhen,&Cheng Gong.(2024).A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes .SCIENCE,384(6693).
MLA：

Zhang Liming, et al. "A naturally isolated symbiotic bacterium suppresses flavivirus transmission by Aedes mosquitoes" .SCIENCE 384,6693(2024).
入库时间：

2024/10/27 22:23:10
更新时间：

2024/10/27 22:23:10
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