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Comprehensive characterization of early-onset lung cancer, in Chinese young adults 期刊论文

编号：

59CAD2D3A8578A6F086E95F3CD83A4B5
作者：

Tian, Ye#^[1]Ma, Rui#^[1]Zhao, Wenchang#^[2]Wang, Shumin^[3];Zhou, Chuanjiang^[4];Wu, Weibing^[5];Yang, Bo^[6];Xin, Hua^[7];Wang, Hongyan^[8];Li, Pengfei^[9];Li, Ranhua^[10];Liu, Changhong^[11];Lu, Yao^[1];Yu, Qian^[1];Song, Chengyang^[1];Zhang, Han^[2];Liang, Ruipu^[2];Zhang, Lei^[1];Zhou, Di^[1];Zhao, Xitong^[1];Wu, Zhuo^[1];Qi, Yafei^[12];Wang, Rui^[13];Fei, Teng*^[2]Yang, Xueying*^[1]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2025 年 16 卷 1 期 ; FEB 26
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摘要：

Early-onset lung cancer in young adults represents a less studied clinical entity with increasing incidence which still affects a large number of cancer patients. Here we perform a comprehensive analysis of early-onset lung cancer for the clinicopathological features, genomic alterations, gene expression, and immune landscape by establishing a cohort enrolling 421 non-small cell lung cancer (NSCLC) patients from ten medical centers in China. Comparative analysis reveals a distinct genomic alteration between younger and elder patients with NSCLC, with ERBB2 mutations and ALK-rearrangement strikingly more frequent in younger group. Transcriptome profiling indicates altered cellular metabolism and immune-related genes in tumors from younger patients. Immunological analysis reveals a decreased infiltration of immune cells (notably T cells) in tumors from younger patients. Cellular and mechanistic studies show that the prevalent ERBB2 mutants in cancer from younger patients can indeed drive tumorigenesis by elevating AKT signaling. Importantly, meta-analysis of clinical trials and our clinical practice further validate the promise of HER2-targeted therapy to treat early-onset NSCLC in East Asian patients. Our comprehensive and integrative analysis not only reveal multiple unrecognized characteristics of early-onset lung cancer, but also inform actionable therapeutics to manage this type of cancer.
推荐引用方式
GB/T 7714：

Tian Ye,Ma Rui,Zhao Wenchang, et al. Comprehensive characterization of early-onset lung cancer, in Chinese young adults [J].NATURE COMMUNICATIONS,2025,16(1).
APA：

Tian Ye,Ma Rui,Zhao Wenchang,Wang Shumin,&Yang Xueying.(2025).Comprehensive characterization of early-onset lung cancer, in Chinese young adults .NATURE COMMUNICATIONS,16(1).
MLA：

Tian Ye, et al. "Comprehensive characterization of early-onset lung cancer, in Chinese young adults" .NATURE COMMUNICATIONS 16,1(2025).
入库时间：

2025/3/18 21:34:08
更新时间：

2025/5/15 5:44:23
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