首页 / 院系成果 / 成果详情页

Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients 期刊论文

编号：

7452FB87FC1284C67902BC84F9B2507E
作者：

Xie, Jing#^[1,2]Liu, Xuhua#^[1,4]Wu, Biaoliang#^[2,3]Chen, Bochong^[1];Song, Qiancheng(宋千成)^[1]Guan, Yuan^[2,3];Gong, Yuanxun^[2,3];Yang, Chengliang^[2,3];Lin, Jinbo^[1];Huang, Mingfeng^[1];Tan, Xinyu^[1,4];Lai, Ruijun^[1,4];Lin, Xiaozhen^[2,3];Zhang, Sheng(张升)^[1]Xie, Xiaoling(谢晓灵)^[1]Chen, Xiaoli^[1];Zhang, Chunyuan^[2,3];Yang, Mei^[2,3];Nong, Huijiao^[2,3];Zhao, Xiaoyang(赵小阳)^[5]Xia, Laixin(夏来新)^[5]Zhou, Weijie(周伟杰)^[6]Xiao, Guozhi(肖国芝)^[7]Jiang, Qing(蒋青)^[8]Zou, Weiguo(邹卫国)^[9]Chen, Di(陈棣)^[10]Lu, Di(陆地)*^[11]Liu, Jia*^[2,3]Bai, Xiaochun(白晓春)*^[1,4]
语种：

英文
期刊：

CELL REPORTS MEDICINE ISSN：2666-3791 2024 年 5 卷 6 期 ; JUN 18
收录：
摘要：

Tibial cortex transverse distraction is a surgical method for treating severe diabetic foot ulcers (DFUs), but the underlying mechanism is unclear. We show that antioxidant proteins and small extracellular vesicles (sEVs) with multiple -tissue regenerative potential are released during bone transport (BT) in humans and rats. These vesicles accumulate in diabetic wounds and are enriched with microRNAs (miRNAs) (e.g., miR-494-3p) that have high regenerative activities that improve the circulation of ischemic lower limbs while also promoting neovascularization, fibroblast migration, and nerve fiber regeneration. Deletion of miR-494-3p in rats reduces the beneficial effects of BT on diabetic wounds, while hydrogels containing miR-494-3p and reduced glutathione (GSH) effectively repair them. Importantly, the ginsenoside Rg1 can upregulate miR-494-3p, and a randomized controlled trial verifies that the regimen of oral Rg1 and GSH accelerates wound healing in refractory DFU patients. These findings identify potential functional factors for tissue regeneration and suggest a potential therapy for DFUs.
推荐引用方式
GB/T 7714：

Xie Jing,Liu Xuhua,Wu Biaoliang, et al. Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients [J].CELL REPORTS MEDICINE,2024,5(6).
APA：

Xie Jing,Liu Xuhua,Wu Biaoliang,Chen Bochong,&Bai Xiaochun.(2024).Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients .CELL REPORTS MEDICINE,5(6).
MLA：

Xie Jing, et al. "Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients" .CELL REPORTS MEDICINE 5,6(2024).
入库时间：

2024/9/1 6:19:29
更新时间：

2024/9/1 6:19:29
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：31  下载次数：0

分享到：

浏览次数：31

下载次数：0

打印次数：0