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A potential association between the characteristics of the multi-organ microbiota and lymph node metastasis in cervical cancer 期刊论文

编号：

74D02E649BF26AC4AFF4522444CFF37E
作者：

Peng, Lan#^[1]Yu, Shuhui^[1];Dong, Yan^[2];Gu, Haifeng^[3];Li, Zheng^[4];Ai, Conghui^[5];Zhang, Lan(张岚)*^[1]Wu, Xingrao^[1];
语种：

英文
期刊：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY ISSN：2235-2988 2026 年 15 卷 ; JAN 20
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关键词：

biomarker cervical cancer lymph node metastasis microbiota predictive models
摘要：

Introduction Microbiota alterations at multiple sites are associated with cervical cancer (CC). However, it is unclear whether CC lymph node metastasis (LNM) is indeed associated with microbiota alterations, whether the microbiota is generally suitable for screening CC LNM-related taxa.Materials and methods We performed 16S rDNA sequencing of samples from oral swabs, feces, urine, and vaginal secretions from CC patients to clarify microbiota characteristics of LNM group. And we constructed a LNM prediction model for CC based on specific flora at each site.Results The alpha-diversity of the urinary microbiota (PSob = 0.0272, PPielou = 0.0278, PShannon = 0.0209 and PSimpson = 0.0465) was reduced in the LNM group compared to the non-LNM group, and significant differences were observed in the structure of the gut (R-2 = 0.0266, P = 0.033) and urine (R-2 = 0.0379, P = 0.002) microbiota between the two groups. The establishment of a predictive model based on oral specific flora, including Erysipelotrichaceae UCG-003 sp., Eubacterium halli group, and Staphylococcus has enabled the differentiation of CC lymph node status. The area under the ROC curve was 0.798. The Yoden index, sensitivity and specificity of this prediction model were 0.520, 57.9% and 94.1%, respectively.Conclusion CC patients with LNM have significant microbiological changes at multiple sites. The predictive model based on oral bacteria can provide a noninvasive and simple method for assessing LNM in CC.
推荐引用方式
GB/T 7714：

Peng Lan,Yu Shuhui,Dong Yan, et al. A potential association between the characteristics of the multi-organ microbiota and lymph node metastasis in cervical cancer [J].FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2026,15.
APA：

Peng Lan,Yu Shuhui,Dong Yan,Gu Haifeng,&Wu Xingrao.(2026).A potential association between the characteristics of the multi-organ microbiota and lymph node metastasis in cervical cancer .FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,15.
MLA：

Peng Lan, et al. "A potential association between the characteristics of the multi-organ microbiota and lymph node metastasis in cervical cancer" .FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 15(2026).
入库时间：

2026/2/17 21:36:48
更新时间：

2026/2/17 21:36:48

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