Objective To compare the psychosocial health and quality of life of children with different types and prism diopters (Delta) of strabismus, and to observe the impact of surgery on the psychosocial health and quality of life of children with strabismus. Methods We use questionnaires to evaluate the scores of perceived discrimination (PD), social anxiety (SAD), self-esteem (S-E), and quality of life (QoL) of children. These indicators are compared between children with and without strabismus, as well as changes before and after strabismus surgery. Results 1. Children with strabismus had lower QoL and S-E scores than those without strabismus, while their SAD and PD scores were higher (p < 0.05). 2. Children with intermittent exotropia had higher QoL scores than the other types of strabismus (p < 0.05), vertical strabismus had higher SAD scores than the other three types (p < 0.05); 3. Patients with exotropia (-15 Delta <= similar to < -30 Delta) had higher sores on QoL and S-E, had lower scores on SAD and individual PD than those with exotropia ( <= -30 Delta) (p < 0.05). Patients with esotropia (+10 Delta <= similar to < +30 Delta) had higher scores on QoL and S-E, had lower scores on group PD than those with esotropia ( >= +30 Delta) (p < 0.05); 4. There were no significant differences in the scores of QoL and S-E between strabismus patients pre and 1 month post-surgery. These scores significantly increased 3 months after surgery (p = 0.000). There were no significant differences in some sub-dimensions of S-E between pre and post-surgery. There were no significant differences in SAD between pre and 1-mon-post-surgery, but it significantly decreased 3 months post-surgery compared to pre-surgery. There were some differences in PD between pre and post-surgery, although they didn't reach the traditional statistical significance level (p = 0.056). Individual PD significantly decreased at 1 and 3 months after surgery (p = 0.010), and group PD significantly decreased at 3 months after surgery (p = 0.048). Conclusion Children with strabismus have lower psychosocial health and quality of life than those without strabismus. The type and severity of strabismus is correlated with mental health and quality of life. Surgery improved S-E and QoL for strabismus patients effectively and reduced PD and SAD. However, these changes exhibit a certain latency, typically occurring 3 months after surgery.