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Assessment of left ventricular systolic function and pathological changes using layer-specific strain in rats with myocardial hypertrophy at various disease stages 期刊论文

编号：

77D17C3D76DA79535098FE01EBADBEE7
作者：

Cui, Li#^[1,2]Wang, Qinghui(王庆慧)^[1,2,3]Luo, Qingyi^[1,2,3]Su, Xuan^[1,2];Zhang, Jian^[1,2];Ding, Yunchuan(丁云川)*^[1,2,3]
语种：

英文
期刊：

INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING ISSN：1569-5794 2025 年 41 卷 6 期 (1103 - 1117) ; JUN
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关键词：

Layer-specific strain 2D-speckle tracking echocardiography Myocardial hypertrophy Myocardial fibrosis Left ventricular dysfunction Rat model
摘要：

PurposeAlthough layer-specific strains are effective for assessing cardiac function, their application in rat models at different stages of myocardial hypertrophy (MH) is immature, and their relationship with MH and myocardial fibrosis (MF) is unclear. This study aimed to investigate changes in layer-specific strains across different disease stages and analyze their association with pathological changes.MethodsA progressive MH rat model was established using isoproterenol injection and categorized into baseline, 1-week, 2-week, 3-week, and 4-week groups. Echocardiographic indices and pathological differences between the five groups were assessed. The correlation between layer-specific strain parameters and cardiomyocyte hypertrophy and MF was analyzed.ResultsAs the disease progressed, the left ventricular (LV) dilated, with the LV wall thickening and then thinning. The left ventricular ejection fraction declined significantly in the fourth week. The endo-myocardial, mid-myocardium and epi-myocardial global longitudinal strain, along with endo-myocardial global circumferential strain (GCS) and the transmural gradient, significantly decreased in the first week, the mid-myocardium GCS in the second week, and continued to decrease as the disease progressed. The epi-myocardial GCS increased in the first week, but then decreased, becoming significantly lower than the baseline group in the third week. The degrees of MH and MF were correlated with the layer-specific strain parameters.ConclusionLayer-specific strains maybe are valuable for early and effective monitoring of LV systolic function and pathological changes in rats with MH. Longitudinal strain is more sensitive to functional changes; endomyocardial strain reflects early LV remodeling and circumferential strain perhaps indicates disease progression and severity.
推荐引用方式
GB/T 7714：

Cui Li,Wang Qinghui,Luo Qingyi, et al. Assessment of left ventricular systolic function and pathological changes using layer-specific strain in rats with myocardial hypertrophy at various disease stages [J].INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING,2025,41(6):1103-1117.
APA：

Cui Li,Wang Qinghui,Luo Qingyi,Su Xuan,&Ding Yunchuan.(2025).Assessment of left ventricular systolic function and pathological changes using layer-specific strain in rats with myocardial hypertrophy at various disease stages .INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING,41(6):1103-1117.
MLA：

Cui Li, et al. "Assessment of left ventricular systolic function and pathological changes using layer-specific strain in rats with myocardial hypertrophy at various disease stages" .INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 41,6(2025):1103-1117.
入库时间：

2025/5/15 4:28:22
更新时间：

2025/5/29 22:36:19
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