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Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice 期刊论文

编号：

7AC8FB59619B331B330E86910ADFFD05
作者：

Guo, Dingming#^[1]Deng, Yun#^[1]Yang, Qianqian^[1];Li, Min^[2];Wang, Xiangfeng^[1];Wan, Xuchun^[1];He, Junqing^[1];Xu, Ying^[1];Huang, Wenxin^[3];Lin, Guohua^[4];Xu, Ya^[5];Sun, Yi*^[5]Zhang, Ruilin(张瑞林)*^[3]Chen, WeiHua(陈卫华)*^[2]Liu, Zhi(刘智)*^[1]
语种：

英文
期刊：

GUT MICROBES ISSN：1949-0976 2024 年 16 卷 1 期 ; DEC 31
收录：
关键词：

Obesity probiotics multi-strain combination symbiotic probiotic community (SPC) species coexistence genome-scale metabolic model (GSMM)
摘要：

Probiotics hold great potential for treating metabolic diseases such as obesity. Given the complex and multifactorial nature of these diseases, research on probiotic combination with multiple targets has become popular. Here, we choose four obesity-related targets to perform high-throughput screening, including pancreatic lipase activity, bile salt hydrolase activity, glucagon-like peptide-1 secretion and adipocyte differentiation. Then, we obtained 649 multi-strain combinations with the requirement that each must cover all these targets in principle. After in vitro co-culture and in vivo co-colonization experiments, only four (<0.7%) combinations were selected as symbiotic probiotic communities (SPCs). Next, genome-scale metabolic model analysis revealed that these SPCs showed lower metabolic resource overlap and higher metabolic interaction potential involving amino acid metabolism (Ammonium, L-Lysine, etc.) and energy metabolism (Phosphate, etc.). Further animal experiments demonstrated that all SPCs exhibited a good safety profile and excellent effects in improving obesity and associated glucose metabolism disruptions and depression-like behaviors in high-fat-diet-fed mice. This anti-obesity improvement was achieved through reduced cholesterol level, fat accumulation and inhibited adipocyte differentiation. Taken together, our study provides a new perspective for designing multi-strain combinations, which may facilitate greater therapeutic effect on obesity and other complex diseases in the future.
推荐引用方式
GB/T 7714：

Guo Dingming,Deng Yun,Yang Qianqian, et al. Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice [J].GUT MICROBES,2024,16(1).
APA：

Guo Dingming,Deng Yun,Yang Qianqian,Li Min,&Liu Zhi.(2024).Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice .GUT MICROBES,16(1).
MLA：

Guo Dingming, et al. "Symbiotic probiotic communities with multiple targets successfully combat obesity in high-fat-diet-fed mice" .GUT MICROBES 16,1(2024).
入库时间：

2024/12/2 21:43:47
更新时间：

2024/12/23 22:30:07

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