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Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women 期刊论文

编号：

9D4A6356D8E7996985E413E3C87F1574
作者：

MinatoInokawa, Satomi#^[1,2]Honda, Mari^[3,4];TsuboiKaji, Ayaka^[1,5];Takeuchi, Mika^[1];Kitaoka, Kaori^[1,6];Kurata, Miki^[1,7];Wu, Bin(吴斌)^[3,8]Kazumi, Tsutomu*^[1,3,9]Fukuo, Keisuke^[1,3,7]
语种：

英文
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2024 年 14 卷 1 期 ; JUL 16
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关键词：

Adipose tissue insulin resistance Homeostasis-model assessment-insulin resistance Body composition Leg fat Trunk fat Skeletal muscle
摘要：

Associations of adipose tissue insulin resistance index (AT-IR, a product of fasting insulin and free fatty acids) with body fat mass and distribution and appendicular skeletal muscle mass (ASM) were compared with results of homeostasis-model assessment-insulin resistance (HOMA-IR) in 284 Japanese female university students and 148 their biological mothers whose BMI averaged < 23 kg/m2. Although mothers compared with daughters had higher BMI, body fat percentage, trunk fat to body fat (TF/BF) ratio and lower leg fat to body fat (LF/BF), AT-IR and HOMA-IR did not differ. We had multivariable linear regression analyses which included TF/BF ratio, LF/BF ratio, weight-adjusted ASM (%ASM), height-adjusted ASM index (ASMI), fat mass index (FMI), and body fat percentage. In young women, AT-IR was independently associated with LF/BF ratio (Standardized beta [S beta]: - 0.139, p = 0.019) and ASMI (S beta: - 0.167, p = 0.005). In middle-aged women, LF/BF ratio (S beta: - 0.177, p = 0.049) and %ASM (S beta: - 0.205, p = 0.02) emerged as independent determinants of AT-IR. HOMA-IR was associated with TF/BF ratio and FMI, a proxy of abdominal and general adiposity, respectively, in both young and middle-aged women. The inverse association of AT-IR with leg fat may support the notion that limited peripheral adipose storage capacity and small skeletal muscle size are important etiological components in insulin-resistant cardiometabolic disease in Japanese women.
推荐引用方式
GB/T 7714：

Minato-Inokawa Satomi,Honda Mari,Tsuboi-Kaji Ayaka, et al. Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women [J].SCIENTIFIC REPORTS,2024,14(1).
APA：

Minato-Inokawa Satomi,Honda Mari,Tsuboi-Kaji Ayaka,Takeuchi Mika,&Fukuo Keisuke.(2024).Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women .SCIENTIFIC REPORTS,14(1).
MLA：

Minato-Inokawa Satomi, et al. "Adipose tissue insulin resistance index was inversely associated with gluteofemoral fat and skeletal muscle mass in Japanese women" .SCIENTIFIC REPORTS 14,1(2024).
入库时间：

2024/11/3 21:41:25
更新时间：

2025/7/4 0:07:58
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