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Greater bone marrow fat and myosteatosis are associated with lower vBMD but not asymptomatic vertebral fracture 期刊论文

编号：

A631B69C2CE9832C6320427C61316020
作者：

Wang, Ling#^[1]Li, Sidong(李思冬)#^[2]Liu, Yandong#^[1]Li, Kai#^[1]Yin, Lu(尹潞)^[3]Su, Yongbin^[1];Guo, Zhe^[1];Xu, Li^[1];Huang, Pengju^[1];Geng, Jian^[1];Zhang, Wenshuang^[1];Ma, Kangkang^[1];Cheng, Kebin^[1];Yan, Dong^[1];Blake, Glen M.^[4]He, Bo(何波)^[5]Liu, Yajun(刘亚军)*^[6]Cheng, Xiaoguang(程晓光)*^[1]
语种：

英文
期刊：

EUROPEAN RADIOLOGY ISSN：0938-7994 2023 年 33 卷 1 期 (578 - 586) ; JAN
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关键词：

Bone marrow fat Myosteatosis Body composition Cancellous bone density Vertebral fracture
摘要：

Objectives Organ fat may affect bone metabolism and be associated with vertebral fracture (VF). This study aimed to explore relationships between VF, adiposity indexes measured by MRI, and volumetric BMD (vBMD) measured by quantitative CT (QCT). Methods Four hundred volunteers, ranging in age from 22 to 83 years, were recruited and underwent same-day abdominal QCT and chemical shift-encoded (CSE) MRI. We used MRI to quantify the fat content of bone marrow (BMF), psoas major and paraspinal muscles, and the liver. Abdominal fat, VF, and vBMD of the lumbar spine were measured by QCT. For VF discrimination analysis, we examined both the whole cohort (60 VF cases in 30 men and 30 women) and a restricted subgroup of those aged over 50 years (50 VF cases in 23 men and 27 women). Results Amongst the men, a 1 SD increase in BMF was associated with a 27.67 (95% CI, -32.71 to -22.62) mg/cm(3) decrease in vBMD after adjusting for age and BMI. Amongst women, all adiposity indexes except for liver fat were significantly associated with vBMD, with BMF having the strongest association (beta, -24.00; 95% CI, -28.54 to -19.46 mg/cm(3)). Similar findings were also observed in participants aged over 50 years. The associations of adiposity indexes with vertebral fracture were not significant after adjusting for age in both sexes aged over 50 years. Conclusions In both sexes, higher bone marrow fat was associated with lower vBMD at the spine. However, marrow fat and other adipose tissues were not associated with radiographic-based prevalent vertebral fractures.
推荐引用方式
GB/T 7714：

Wang Ling,Li Sidong,Liu Yandong, et al. Greater bone marrow fat and myosteatosis are associated with lower vBMD but not asymptomatic vertebral fracture [J].EUROPEAN RADIOLOGY,2023,33(1):578-586.
APA：

Wang Ling,Li Sidong,Liu Yandong,Li Kai,&Cheng Xiaoguang.(2023).Greater bone marrow fat and myosteatosis are associated with lower vBMD but not asymptomatic vertebral fracture .EUROPEAN RADIOLOGY,33(1):578-586.
MLA：

Wang Ling, et al. "Greater bone marrow fat and myosteatosis are associated with lower vBMD but not asymptomatic vertebral fracture" .EUROPEAN RADIOLOGY 33,1(2023):578-586.
入库时间：

2022/8/27 21:48:34
更新时间：

2022/8/27 21:48:34
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