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The Effects of Probiotic Supplementation on Anthropometric Growth and Gut Microbiota Composition in Patients With Prader-Willi Syndrome: A Randomized Double-Blinded Placebo-Controlled Trial 期刊论文

编号：

A9570A71D23504122C13201AB16D3B1B
作者：

Kong, XueJun#*^[1,2]Wan, Guobin(万国斌)^[3]Tian, Ruiyi^[1];Liu, Siyu^[1];Liu, Kevin^[1];Clairmont, Cullen^[1];Lin, Xiaojing^[4];Zhang, Xiaoying^[5];Sherman, Hannah^[1];Zhu, Junli^[6];Wang, Yelan^[7];Fong, Michelle^[1];Li, Alice^[1];Wang, Bryan K.^[8];Wang, Jinghan^[9];Liu, Jun^[1,10];Yu, Zhehao^[11];Shen, Chen^[11];Cui, Xianghua^[11];Cao, Hanyu^[11];Du, Ting^[11];Cao, Xia(曹霞)^[11]
语种：

英文
期刊：

FRONTIERS IN NUTRITION ISSN：2296-861X 2021 年 8 卷 ; FEB 19
收录：
关键词：

Prader-Willi syndrome microbiome probiotics Bifidobacterium animalis subsp lactis obesity inflammation height microbiota (microorganism)
摘要：

Background: Prader-Willi Syndrome (PWS) is a rare genetic disorder associated with developmental delay, obesity, and neuropsychiatric comorbidities. Bifidobacterium animalis subsp. lactis has demonstrated anti-obesity and anti-inflammatory effects in previous studies. Aim: To evaluate the effects of Bifidobacterium animalis subsp. lactis probiotics supplementation on anthropometric growth, behavioral symptoms, and gut microbiome composition in patients with PWS. Methods: Ethical Approval was issued by the Internal Review Board (IRB) of the Second Affiliated Hospital of Kunming Medical University (Review-YJ-2016-06). We conducted a 12-week, randomized, double-blind, placebo-controlled trial in 68 patients with Prader-Willi syndrome aged 11 months-16 years (mean = 4.2 years old) who were randomly assigned to receive daily B. lactis-11 probiotics (6 x 10(10) CFUs) or a placebo sachet. Weight, height, ASQ-3, ABC, SRS-2, and CGI-I were compared between the two groups at baseline and at 6 and 12 weeks into treatment. Gut microbiome data were analyzed with the QIIME 2 software package, and functional gene analysis was conducted with PICRUSt-2. Results: We found a significant increase in height (mean difference = 2.68 cm, P < 0.05) and improvement in CGI-I (P < 0.05) in the probiotics group compared to the placebo group. No significant change in weight or psychological measures were observed. Probiotic treatment altered the microbiome composition to favor weight loss and gut health and increased the abundance of antioxidant production-related genes. Conclusions: The findings suggest a novel therapeutic potential for Bifidobacterium animalis subsp. lactis probiotics in Prader-Willi syndrome patients, although further investigation is warranted.
推荐引用方式
GB/T 7714：

Kong Xue-Jun,Wan Guobin,Tian Ruiyi, et al. The Effects of Probiotic Supplementation on Anthropometric Growth and Gut Microbiota Composition in Patients With Prader-Willi Syndrome: A Randomized Double-Blinded Placebo-Controlled Trial [J].FRONTIERS IN NUTRITION,2021,8.
APA：

Kong Xue-Jun,Wan Guobin,Tian Ruiyi,Liu Siyu,&Cao Xia.(2021).The Effects of Probiotic Supplementation on Anthropometric Growth and Gut Microbiota Composition in Patients With Prader-Willi Syndrome: A Randomized Double-Blinded Placebo-Controlled Trial .FRONTIERS IN NUTRITION,8.
MLA：

Kong Xue-Jun, et al. "The Effects of Probiotic Supplementation on Anthropometric Growth and Gut Microbiota Composition in Patients With Prader-Willi Syndrome: A Randomized Double-Blinded Placebo-Controlled Trial" .FRONTIERS IN NUTRITION 8(2021).
入库时间：

2021/3/24 5:12:28
更新时间：

2021/3/24 5:12:28
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