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Protective effect of oleuropein on the brain tissue in D-Galactose-induced aging in rat model  期刊论文  

  • 编号:
    BC84DF262F39A96827BA272CB60750B0
  • 作者:
    Hu, Xiaofang#[1]Zhao, Nan[2];Ranjbar, Elham*[3]Foruozandeh, Hossein[4];Nahal, Ali seidkhani[5];Asadoola, Yousef[6];Ahmadi, Iraj*[7]
  • 语种:
    英文
  • 期刊:
    MOLECULAR BIOLOGY REPORTS ISSN:0301-4851 2025 年 52 卷 1 期 ; DEC
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  • 关键词:
  • 摘要:

    Background Oleuropein (OLE) has the potential to reduce oxidative stress and inflammation. So, in the present investigation, we explored the protective effect of OLE on brain aging induced by d-galactose (D-Gal) in a rat model. Methods and results 40 Wister male adult rats were categorized into 5 groups. Group 1 received normal saline; group 2 was given 100 mg/kg of D-Gal intraperitoneally (IP). The rats in groups 3 to 5 were given D-Gal (100 mg/kg, IP) along with different doses of OLE (20, 40, and 80 mg/kg, respectively) orally. All administrations were performed daily for 8 weeks. 24 h after last treatment motor activity and memory impairment were evaluated. Then, the rats were euthanized and brain samples were collected for evaluating the levels of malondialdehyde (MDA), Brain-Derived Neurotrophic Factor (BDNF), protein carbonyl (PC), glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), Superoxide dismutase (SOD), Tumor necrosis factor alpha (TNF-alpha), interleukin 1 beta ( IL-1 beta), as well as Sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1) gene expression. The results showed that D-Gal significantly reduced motor activity and memory performance (P < 0.05). It also significantly reduced the GPX, CAT and SOD activities, GSH and BDNF levels as well as SIRT1 and PGC1 expression, and, significantly increased PC, MDA TNF-alpha and IL-1 beta levels in the brain tissue (P < 0.05). Administration of OLE restored all of the above parameters close to control group. Conclusion The findings demonstrated that OLE, through its antioxidant and anti-inflammatory properties, improved motor activity, memory impairment, and age-related neurological dysfunction.

  • 推荐引用方式
    GB/T 7714:
    Hu Xiaofang,Zhao Nan,Ranjbar Elham, et al. Protective effect of oleuropein on the brain tissue in D-Galactose-induced aging in rat model [J].MOLECULAR BIOLOGY REPORTS,2025,52(1).
  • APA:
    Hu Xiaofang,Zhao Nan,Ranjbar Elham,Foruozandeh Hossein,&Ahmadi Iraj.(2025).Protective effect of oleuropein on the brain tissue in D-Galactose-induced aging in rat model .MOLECULAR BIOLOGY REPORTS,52(1).
  • MLA:
    Hu Xiaofang, et al. "Protective effect of oleuropein on the brain tissue in D-Galactose-induced aging in rat model" .MOLECULAR BIOLOGY REPORTS 52,1(2025).
  • 入库时间:
    2025/1/7 12:08:25
  • 更新时间:
    2025/1/13 22:33:08
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