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Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation  期刊论文  

  • 编号：
    BF0E14CA8EDC2447978C0BE64E3829D1
  • 作者：
    Chen, Xiao#[1,2]Lu, Bin#[1,2,3]Wang, YuWei[1,2];Li, XueYing[1,2];Wang, ZiHan[1,2];Li, HuiXian[4];Liao, YiFan[1,2];Blumberger, Daniel M.[5,6];Castellanos, Francisco Xavier[7,8];GarzaVillarreal, Eduardo A.[9];Cao, LiPing[10];Chen, GuanMao[11];Chen, JianShan[10];Chen, Tao[12];Chen, TaoLin[13,14,15];Chen, YanRong[1,16];Cheng, YuQi(程宇琪)[17]Chu, ZhaoSong[17];Cui, ShiXian[1,18,19];Cui, XiLong[20,21];Deng, ZhaoYu[1,2];Gao, QingLin[1,2];Gong, QiYong[13,14,15];Guo, WenBin[20,21];He, CanCan[22];Hu, ZhengJiaYi[1,18,19];Huang, Qian[23];Ji, XinLei[20,21];Jia, FengNan[24];Kuang, Li[23];Li, BaoJuan[25];Li, Feng[26];Li, Tao[27,28,29,30];Li, Xue[1,2];Lian, Tao[1,2];Liu, XiaoYun[31];Liu, YanSong[24];Liu, ZheNing[20,21];Long, YiCheng[20,21];Lu, JianPing[32];Qiu, Jiang[33];Shan, XiaoXiao[20,21];Si, TianMei[34,35];Sun, PengFeng[36];Wang, ChuanYue[26];Wang, HanLin[1,18,19];Wang, Xiang[20,21];Wang, Ying[11];Wu, ChenNan[1,2];Wu, XiaoPing[36];Wu, XinRan[33];Wu, YanKun[34,35];Xie, ChunMing[22];Xie, GuangRong[20,21];Xie, Peng(谢鹏)[37,38,39]Xu, XiuFeng(许秀峰)[17]Xue, ZhenPeng[32];Yang, Hong[12];Yang, Jian[38];Yu, Hua[27,28,29,30];Yu, YongQiang[40,41,42];Yuan, MinLan[43];Yuan, YongGui[31];Zang, YuFeng[44,45];Zhang, AiXia[46];Zhang, KeRang[46];Zhangal, Wei[43];Zhang, ZiJing[1,2];Zhao, JingPing(赵靖平)[20,21]Zhu, JiaJia[40,41,42];Zuo, XiNian[47,48];Wang, HuaNing[25];Yan, ChaoGan*[1,2,18,19,49,50]
  • 语种：
    英文
  • 期刊：
    SCIENCE BULLETIN ISSN：2095-9273 2025 年 70 卷 16 期 (2676 - 2690) ; AUG 30
  • 收录：
     
  • 关键词：
    Major depressive disorder Transcranial magnetic stimulation Individualization Subgenual anterior cingulate cortex Functional connectivity Dual regression
  • 摘要：

    The subgenual anterior cingulate cortex (sgACC) plays a central role in the pathophysiology of major depressive disorder (MDD). Its functional interactive profile with the left dorsal lateral prefrontal cortex (DLPFC) is associated with transcranial magnetic stimulation (TMS) treatment outcomes. Previous research on sgACC functional connectivity (FC) in MDD has yielded inconsistent results, partly due to small sample sizes and limited statistical power. Furthermore, calculating sgACC-FC to target TMS individually is challenging. We used a large multi-site cross-sectional sample (1660 patients with MDD vs. 1341 healthy controls) from Phase II of the Depression Imaging REsearch ConsorTium (DIRECT) to systematically delineate case-control difference maps of sgACC-FC. We explored the potential impact of group-level abnormality profiles on TMS target localization and clinical efficacy. Next, we developed an MDD big data-guided, individualized TMS targeting algorithm to integrate group-level statistical maps with individual-level brain activity to individually localize TMS targets. We found enhanced sgACC-DLPFC FC in patients with MDD compared with healthy controls (HC). These group differences altered the position of the sgACC anti-correlation peak in the left DLPFC. We showed that the magnitude of case-control differences in the sgACC-FC was related to clinical improvement in two independent clinical samples. This targeting algorithm may generate targets demonstrating stronger associations with clinical efficiency than group-level targets. We reliably delineated MDD-related abnormalities of sgACC-FC profiles in a large, independently ascertained sample and demonstrated the potential impact of such case-control differences on FC-guided localization of TMS targets. (c) 2025 The Authors. Published by Elsevier B.V. and Science China Press. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

  • 推荐引用方式
    GB/T 7714：
    Chen Xiao,Lu Bin,Wang Yu-Wei, et al. Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation [J].SCIENCE BULLETIN,2025,70(16):2676-2690.
  • APA：
    Chen Xiao,Lu Bin,Wang Yu-Wei,Li Xue-Ying,&Yan Chao-Gan.(2025).Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation .SCIENCE BULLETIN,70(16):2676-2690.
  • MLA：
    Chen Xiao, et al. "Subgenual anterior cingulate cortex functional connectivity abnormalities in depression: insights from brain imaging big data and precision-guided personalized intervention via transcranial magnetic stimulation" .SCIENCE BULLETIN 70,16(2025):2676-2690.
  • 入库时间：
    2025/10/10 0:56:51
  • 更新时间：
    2025/10/10 0:56:51
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