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Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers 期刊论文 WOS高被引论文

编号：

C4955020315AA86E0FF0E3A3FECC135F
作者：

Sun, Yang(孙杨)#^[1]Zhang, Xiang#^[2]Hang, Dong(杭栋)#^[2,3]Lau, Harry CheukHay#Du, Jie#^[4]Liu, Chuanfa^[2];Xie, Mingxu^[2];Pan, Yasi^[2];Wang, Le^[5];Liang, Cong^[6];Zhou, Xingyu^[2];Chen, Danyu^[2];Rong, Jiamei^[1];Zhao, Zengren(赵增仁)^[7]Cheung, Alvin HoKwan^[8];Wu, Yuet^[2];Gou, Hongyan^[2];Wong, Chi Chun(黄子隽)^[2]Du, Lingbin(杜灵彬)^[5]Deng, Junliang^[4];Hu, Zhibin(胡志斌)^[3]Shen, Hongbing(沈洪兵)*^[3]Miao, Yinglei(缪应雷)*^[1]Yu, Jun(于君)*^[2]
语种：

英文
期刊：

CANCER CELL ISSN：1535-6108 2024 年 42 卷 8 期 ; AUG 12
收录：
摘要：

Changes in plasma and fecal metabolomes in colorectal cancer (CRC) progression (normal-adenoma-CRC) remain unclear. Here, plasma and fecal samples were collected from four independent cohorts of 1,251 individuals (422 CRC, 399 colorectal adenoma [CRA], and 430 normal controls [NC]). By metabolomic profiling, signature plasma and fecal metabolites with consistent shift across NC, CRA, and CRC are identified, including CRC-enriched oleic acid and CRC-depleted allocholic acid. Oleic acid exhibits pro-tumorigenic effects in CRC cells, patient-derived organoids, and two murine CRC models, whereas allocholic acid has opposing effects. By integrative analysis, we found that oleic acid or allocholic acid directly binds to a-enolase or farnesoid X receptor-1 in CRC cells, respectively, to modulate cancer-associated pathways. Clinically, we establish a panel of 17 plasma metabolites that accurately diagnoses CRC in a discovery and three validation cohorts (AUC = 0.848-0.987). Overall, we characterize metabolite signatures, mechanistic significance, and diagnostic potential of plasma and fecal metabolomes in CRC.
推荐引用方式
GB/T 7714：

Sun Yang,Zhang Xiang,Hang Dong, et al. Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers [J].CANCER CELL,2024,42(8).
APA：

Sun Yang,Zhang Xiang,Hang Dong,Lau Harry Cheuk-Hay,&Yu Jun.(2024).Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers .CANCER CELL,42(8).
MLA：

Sun Yang, et al. "Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers" .CANCER CELL 42,8(2024).
入库时间：

2024/11/10 22:27:15
更新时间：

2024/11/10 22:27:15

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